Inhibition of the mitochondrial calcium uniporter (MCU) rescues dopaminergic neurons in pink1-/- zebrafish
Objective: To further elucidate the interaction between mitochondrial calcium homeostasis and PINK1 deficiency in a zebrafish (Danio rerio) model of Parkinson's disease (PD). Background: Loss…Systematic review of autosomal recessive parkinsonism using the MDGene database protocol
Objective: A systematic review of autosomal recessive parkinsonism using DJ-1 as an example. Background: MDGene is a genotype-phenotype database for rare mutations in movement disorders…Two cases of parkinsonism with atypical genetics
Objective: To report and discuss two unrelated patients carrying heterozygous mutations in both Parkin (PARK2) and Glucocerebrosidase (GBA) gene, with atypical Parkinsonian features. Background: Parkin…Same cerebellar atrophy pattern in hyper- and hypokinetic movement disorders due to mitochondrial cytopathy
Objective: To describe the prevalence and phenotype of movement disorders (MDs) in patients with mitochondrial cytopathy (MC) and corresponding pattern of cerebral atrophy. Background: MCs…Polyethylenimine (PEI) nanoparticle-mediated delivery of siRNA to silence neuronal gene expression of alpha-synuclein in a mouse model of Parkinson’s disease
Objective: To develop novel therapeutic strategies for movement disorders by interfering with neuronal gene expression, PEI nanoparticle-mediated delivery of RNA was investigated in vivo. Background:…The correlation between N30 SEP and motor function in Parkinson’s disease
Objective: To investigate frontal N30 in Parkinson's disease (PD), and to examine the correlation between amplitude of frontal N30 and the degree of motor deficits.…Postural and nonmotor disturbances in Parkinson’s disease
Objective: To investigate postural impairments (PI) and their interrelation with non-motor symptoms in patients with Parkinson's disease (PD). Background: PI mechanisms are only partially known.…Bi-hemispheric phase synchronization in patients with Parkinson’s disease during stance, gait and upper limb motor tasks
Objective: To begin exploring if and how bi-hemispheric cortical phase synchronization (PS), as reflected by electroencephalography (EEG), during free overground walking, is associated with gait…The epigenetic regulation of HIF-1α by SIRT1 in MPP+ treated SH-SY5Y cells
Objective: Both silent information regulator 1 (SIRT1) and hypoxia inducible factor 1 (HIF-1) have been found to play important roles in the pathophysiology of Parkinson's…Role of macroautophagy in regulating microglia-mediated neuroinflammation and dopaminergic neuron injury
Objective: To investigate the potential role of macroautophagy in the regulation of microglia-mediated neuroinflammation and dopamine neuron injury. Background: Chronic neuroinflammation, a process mediated by…
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