Mild mitochondrial impairment promotes corticostriatal synaptic plasticity alterations in PINK1 heterozygous knockout mice
Objective: To investigate the effects of the exposure to low-dose rotenone of heterozygous PINK1 knockout (PINK1+/-) mice, compared to their wild-type littermates (PINK1+/+), on dopamine-dependent…Sodium butyrate attenuates rotenone-induced neurodegeneration via enhancing autophagy and preventing α-synuclein aggregation
Objective: To investigate whether sodium butyrate (NaB) could enhance autophagy and thus exert a neuroprotective effect through the modulation of α-synuclein in animal models of…Molecular landscape of Parkinson’s disease reveals a key role for lipids and lipoproteins
Objective: Integrate available genetic and expression data to generate a molecular landscape of Parkinson's disease (PD) in order to identify key disease mechanisms that may…Cortical role in the freezing of gait in Parkinson’s disease
Objective: In this study, we aimed to investigate the neural underpinning of freezing of gait (FOG) in Parkinson's disease (PD), especially the role of the…Age associated effects of levodopa administration on striatal acetylcholinesterase activity
Objective: The aim of this study was to compare short- and long-term effects of levodopa on acetylcholinesterase activity in young and old rat brain striatum.…Beyond initial clinical phenotype of Madelung disease: Myoclonus, gait disorder and multisystem involvement led to genetic diagnosis
Objective: To report the clinical phenotype of an uncommon hereditary systemic disease with slowly progressive gait and movement disorder with genetic identification of two concurrent…Persistent myoclonic dystonia due to SCL2A1 mutation
Objective: We present a young woman with myoclonic dystonia due to a novel mutation in SCL2A1 gene. Background: Mutations in the SCL2A1 gene can cause…Safety and efficacy of escalating doses of incobotulinumtoxinA (400-800U): Increasing improvements in disability due to multifocal upper- and lower-limb spasticity
Objective: To assess the safety and efficacy of escalating incobotulinumtoxinA doses (400-800U) in patients with spasticity. Background: Botulinum toxin treatment at higher doses than currently…Do different tic phenotypes have different responses to comprehensive behavioral intervention for tics (CBIT)?
Objective: To evaluate 1) the types of tics undergoing CBIT at an expert movement disorders center and 2) to evaluate the response of each tic…Altered connectivity within the cerebello-thalamo-cortical network in essential tremor: A resting state fMRI study
Objective: To evaluate the tremor network in Essential Tremor(ET) patients in rest conditions with respect to Healthy Controls(HC). Background: Pathophysiology of ET is poorly understood.…
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