Drp1 inhibition amelioratesα-synuclein-mediated neurodegeneration in rats
Objective: To provide new insights on the relationships occurring between mitochondria physiology and α-synuclein (α-syn) accumulation in an animal model of progressive neurodegeneration. Background: In…Impact of prolonged temporal discrimination threshold on finger movements of Parkinson’s disease
Objective: In present study, we investigated the impact of temporal discrimination threshold (TDT) prolongation on simple repetitive finger tapping and dexterous finger movement in patients…Lessons learned from the Nilotinib trial: Cardio-vascular conditions in parkinsonism
Objective: A retrospective records review of 9 patients that failed screening for a clinical trial was performed to examine the co-morbid cardiac manifestations of PD…Effects of Arachidonyl-2′-chloroethylamide (ACEA), a selective CB1 receptor agonist, in MPTP mouse model of Parkinson’s disease
Objective: Cannabinoids have been demonstrated to be effective in preclinical studies involving oxidative stress, neuroinflammation, and motor complications associated with Parkinson's disease (PD).The CB1 cannabinoid…Discrimination of Parkinson’s disease participants from healthy controls using telephone-quality voice recordings
Objective: To test the practicality and efficacy of telephone-quality voice recordings to discriminate Parkinson's disease (PD) participants from healthy controls (HC). Background: Vocal performance degradation…Disease severity is not predictive of the dose required for apomorphine sublingual film (APL-130277) to convert a patient with Parkinson’s disease from OFF to fully ON
Objective: Evaluate whether baseline disease severity is predictive of the effective APL-130277 dose to turn a patient with Parkinson's disease (PD) from OFF to fully…Increased cerebrospinal fluid lactate levels in Parkison’s disease: Is it a proof of mitochondrial inefficiency?
Objective: The aim of the present study was to investigate the impairment of neuronal energy metabolism, as measured by means of cerebrospinal fluid (CSF) lactate…Cognitive and depressive behavior changes in aged mice with heterozygous deletions of VMAT2 or of DAT
Objective: To evaluate cognitive and depressive behavior in aged mice with heterozygous deletions of vesicular monoamine transporter (VMAT2) or of Dopamine transporter (DAT). Background: VMAT2…Intrastriatal injection of ionomycin profoundly changes motor response to L-DOPA and its underlying molecular mechanisms
Objective: We investigated whether intrastriatal injection of ionomycin to hemiParkinsonian rats produced changes in L-DOPA responses including LID and analyzed the effects of ionomycin on…Drug-induced parkinsonism in Taiwan
Objective: To review drug-induced parkinsonism (DIP) in Taiwan. Background: Drug-induced parkinsonism (DIP) is a frequent etiology of secondary parkinsonism. DIP must always be suspected when…
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