Counteracting PINK1/parkin deficiency by activating alternative mitophagic pathway: a potential therapeutic intervention for Parkinson’s disease
Objective: To identify a new therapeutic target for developing neuroprotective treatment in Parkinson's disease (PD) by improving mitochondrial function through restoration of mitochondrial quality control…Opioid K receptor variant delays the onset of dyskinesias in Parkinson’s disease
Objective: To investigate the genetic factors modulating the timing of the onset of levodopa-induced dyskinesias (LIDs) in Parkinson's disease (PD). Background: Pathophysiological mechanisms underlying LIDs…Multidisciplinary group program integrating voice and dance movement therapy for Parkinson’s disease patients: Preliminary experience
Objective: To examine the effects of “Voice in Motion“ group therapy on movement, speech and QOL of PD patients. Background: Physical exercise and speech therapy…Modulating neuronal activity in dopaminergic neurons to promote their survival
Objective: To manipulate the activity of dopaminergic (DA) neurons in culture using pharmacological and molecular tools to promote their survival. Background: Parkinson's disease is a…Alpha-synuclein – super-resolution microscopy reveals potential new role of alpha-synuclein at the pre-synapse
Objective: Alpha-synuclein is a major key player in Parkinson's disease, however its physiological function still remains elusive. Using super-resolution microscopy this study aims to analyse…The effect of STN-DBS on movement initiation control is modulated by the noradrenergic system: Evidence of an interaction from a combined pharmacological/DBS/EEG study
Objective: Assessing the role of the noradrenergic system underlying the effect of subthalamic nucleus stimulation (STN-DBS) on akinesia. Background: Slowness in movement initiation, associated with…Treatment of OFF episodes in Parkinson’s disease: An evaluation of patient and caregiver insights
Objective: Evaluate patient and caregiver opinions into the treatment of OFF episodes in patients with Parkinson's disease (PD). Background: OFF episodes are fairly common in…Synaptic homeostasis in Parkinson’s disease: An high-density EEG study in different stage of the disease
Objective: In order to corroborate these findings, we submitted 29 Parkinson's disease (PD) patients with different stage of disease to an all-night high-density EEG (hd-EEG)…Detailed proteomic analysis of early PD brain highlights altered expression of mitochondrial proteins as an important event in sporadic PD
Objective: To uncover early pathogenic events occurring prior to neuronal loss and Lewy body formation in human PD brain. Background: In PD, pathological changes spread…Lrrk2 alleles modify host response to microbial infections
Objective: The mechanisms by which allelic changes in LRRK2 modulate the susceptibility to Parkinson's disease, Crohn's disease and leprosy remain unknown. We hypothesized that leucine-rich…
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