Objective: To analyze lung function and respiratory muscle strength (RMS) of elderly with PD in early stages (Hoehn & Yahr scale 0-3).

Background: Parkinson’s disease (PD) has also been associated with ventilatory disorders it since its first description. Perhaps of the difficulty in conducting ventilatory volitional tests in individuals with PD, there is no consensus about the function and respiratory muscle strength of these individuals.

Method: An observational study with ethical approval (CAAE: 70479517.2.0000.5020). Spirometry was performed according to ATS/ERS criteria. Maximal inspiratory pressure (MIP) and maximal expiratory pressure (MEP) was performed according to Black and Hyatt. After performing a sample calculation, we studied 154 elderly with a median age of 69.0 years divided into two groups: PD group (PG) and control group (CG), matched for sex, age, and body mass index. The participants were recruited from four centers for the care of the elderly and a center specializing in Movement Disorders in the Manaus, Amazonas, Brazil. PG: 77 independent ambulatory elderly with PD under pharmacological treatment with levodopa. The test was performed in the ‘on’ state, 60-90 min after levodopa therapy. CG: 77 independent elderly without diagnosis of cardiorespiratory or neurological diseases. Were excluded smokers, with previous diagnosis of pulmonary dysfunction or other concomitant neurological diseases and who did not present physical/cognitive conditions for the tests. The Pearson’s chi-square test and the Mann-Whitney test were used for level of significance in the statistical tests 5%.

Results: PG: Diagnostic time of PD ranged from 0.5 to 23 years. 68.8% presented ventilatory disorder. The restrictive disorder was the most prevalent (45%), 23.4% of obstructive disorder and 31,8% of normality. GC: 44.2% presented ventilatory disorder. The prevalence of restrictive disorder was of 26%, 18,2% obstructive disorder and 55,8% of normality (Pearson’s chi-square test P=0,007 PG X CG). The MIP of the PG was -80 cm H₂O and the GC -70 cm H₂O (p= 0,725 Mann-Whitney test). The MEP of the PG was + 94,9 cm H₂O and the GC +84,3 cm H₂O (p= 0,085 t-student test). The MIP and MEP were in accordance with the reference values (Neder´s equation).

Conclusion: Elderly in early-stage PD had a higher prevalence of restrictive disorder and there was no respiratory muscle weakness.

References: POEWE, W.; SEPPI, K.; TANNER, C. M.; HALLIDAY, G. M.; BRUNDIN, P.; VOLKMANN, J. et al. Parkinson disease. Nature Reviews Disease Primers, v. 3, p. 1-21, 2017. O’CALLAGHAN, A.; WALKER, R. A review of pulmonary function in Parkinson’s disease. Journal of Parkinsonism and Restless Legs Syndrome, v. 8, p. 13-23, 2018. BAILLE, G.; DE JESUS, A. M.; PEREZ, T.; DEVOS, D.; DUJARDIN, K.; CHARLEY, C. M. et al. Ventilatory dysfunction in Parkinson’s disease. Journal of Parkinson’s Disease, v. 6, n. 3, p. 463-471, 2016. GONÇALVES, R. L.; NETO, J. C. B.; SILVA, C. D. A.; DE LEON, E. B.; SANCHEZ, F. F. Respiratory Function and the Influence of Inspiratory Muscle in Vital Capacity in Parkinsons Disease. Journal of Novel Physiotherapies, v. 6, n. 6, p. 1000319, 2016. TORSNEY, K. M.; FORSYTH, D. Respiratory dysfunction in Parkinson’s disease. Journal of the Royal College of Physicians of Edinburghv, v. 47, n. 1, p. 35-39, 2017.

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