Objective: To validate PRO-PD in a random sample of outpatients with PD.

Background: Successful treatment of Parkinson’s disease (PD) requires symptom monitoring. Patient-Reported Outcomes in Parkinson’s Disease (PRO-PD) is a broad scale that covers 35 motor and non-motor symptoms, but its validation is limited [1].

Method: Out of 2123 PD patients who visited outpatient clinics in West Sweden over a 12-month period, 25% were randomly selected and invited to participate in a longitudinal observational study. Included patients were assessed at baseline, 1 year and 3 years, with a subset also assessed at 3–6 months. The assessments included PRO-PD, other patient-reported scales and Clinical Impression of Severity Index (CISI-PD).

Results: The study included 286 PD patients (65% male, median age 73 years, median time since diagnosis 5.3 years). In all, PRO-PD ratings were available from 716 (96%) out of 747 study visits, with a median score of 995 at baseline (range 55 to 3438) and a median yearly increase of 71 (interquartile range -21 to 111). Items representing axial motor symptoms increased most over time. All PRO-PD items exhibited positive skewness without ceiling effects. Internal consistency at baseline was excellent (Cronbach’s alpha: 0.93). Six-month test-retest reliability was good (intraclass correlation coefficient: 0.87). Convergent validity was good, with correlation coefficients between total PRO-PD and the 8-item Parkinson’s Disease Questionnaire of 0.70, the Non-Motor Symptoms Questionnaire of 0.70, EuroQoL 5-Dimension 5-Level Scale of 0.71 and CISI-PD of 0.69.

Conclusion: PRO-PD was found reliable and valid for monitoring symptoms in a representative sample of outpatients with PD.

References: 1. Mischley et al., npj Parkinson’s Disease (2017) 3:20.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/validation-of-the-patient-reported-outcomes-in-parkinsons-disease-scale-in-outpatients/