Objective: We studied clinical features and the levels of glucose in blood of patients with idiopathic PD (IPD) of different sages and duration who had recently (not more than 6 weeks) suffered an acute psychoemotional stress (loss of a spouse, parents, job, etc.).

Background: Recent literature suggests that diabetes is a risk factor for Parkinson’s disease (PD). However, there no evidence that transient mild hyperglycemia could be an independent diagnostic factor in Parkinson’s disease (PD) after acute psychoemotional stress.

Methods: We investigated total 54 patients with IPD. 25 PD patients who had recently undergone acute psychoemotional stress were the main group. The other 29 PD patients (comparative group) had no any strong stress. Our studies were based on the Unified Parkinson’s disease Rating Scale (UPDRS), Hoehn & Yahr staging, gender, body mass index (± 1 kg/m2), and duration of PD (±1 year). In all the patients were carried out biochemical analyses to identify the level of glucose in blood.

Results: In patients with PD who had suffered acute psychoemotional stress the levels of glucose in blood were 7.4±0.05 mmol/l in the morning on the empty stomach, 8.6±0.17 mmol/l after 2 hours after breakfast, and 8.9±0.12 mmol/l after 2 hours after lunch. There were no significant differences between glucose levels, stage and duration of PD. The more body mass index was (more than 90 kg/m2), the glucose levels were elevated. The most PD patients with transient mild hyperglycemia trended to deviations in nutrition.

Conclusions: Our data suggest that a strong stress in patients with Parkinson’s disease causes complications in the form of transient mild hyperglycemia which could provoke development of secondary diabetes in PD patients.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/transient-mild-hyperglycemia-as-diagnostic-tool-for-idiopatic-parkinsons-disease-triggered-by-psychoemotional-stress/