Objective: To explore the efficacy of one TCM formula, Lian-Se granule (LSG), in treating for salivation and nocturia for patient with Parkinson’s disease (PD).

Background: There is no effective treatments for salivation and nocturia of PD. The two symptoms are caused by Kidney weak and insufficiency of the spleen in TCM theory, and the LSG has been thought can stop salivation and control the nocturia for this type patients of PD.

Methods: 50 suffering with salivation and/or nocturia patients with PD who are outpatients or in-patients from Shuguang hospital were collected to divided into two groups, LSG group which will be treated additionally by LSG (which contains four type of traditional Chinese herbs) and others is control group who will be treated by placebo granule, which appearance and testy is same with LSG four weeks. All patients will be treated by standard anti-pakinsonism medicine according to the PD guideline of China. The nocturia times (NT) and the total score of United Parkinson’s Disease Rate Scale (UPDRS) and the sixth of UPDRRS II (Salivation, UPDRS II-6) have been used to evaluate the clinical efficacy for both groups.

Results: There are no significant differences were found for the baseline of NT (4.3±1.7 for LSG and 4.2±1.9 for placebo group), UPDRS total score (37.97 ± 10.51 for LSG group and 38.15 ± 6.78 for placebo group, p=0.23) and UPDRS II-6 (2.52 ±0.37 for LAG and 2.49 ±0.42 for placebo group, p=0.17). At the end of week 4, there is one patient withdraw from the study for LSG group without any reason, and two patients withdraw for the study from placebo group (one complaint lack effect and another complaint the bitter testy and lack effect). The NT is 2.2±1.5 for LSG group and 4.03±1.9 for placebo group (p=0.037). The total score of UPDRS is 37.03 ± 6.74 for LSG and 38.79 ± 5.87 for placebo group respectively (p=0.072). The UPDRS II-6 is 2.01 ± 0.46 for LSG and 2.51 ± 0.52 for placebo group, the difference was significant (P<0.044) at the end of week 4. There are no any side effects were found for both groups by laboratory tests.

Conclusions: These findings indicate clear differences for NT and UPDRS II-6 at the end of week 4 compared with before treatment for the LSG group. Non-RCT and insufficient cases are the shortages for our study. In order to validate the causes of the disease based on clinical data, large-scale, multicenter, double-blind randomized control studies may be needed to verify the effectiveness of LSG in the treatment of salivation and nocturia for patient with PD.

References: 1. Pan W, Kwak S, Liu Y, Sun Y, Fang Z, Qin B, Yamamoto Y. Traditional Chinese medicine improves activities of daily living in Parkinson’s disease. Parkinson’s Disease. 2011. doi:10.4061/2011/789506. 2. Pan W, Kwak S, Liu Y, Fang Z, et al. A compound belonging to traditional Chinese medicine improves nocturnal activity in Parkinson’s disease. Sleep med. 2011;12:307-308. 3. Pan W, Kwak S, Li G, Chen Y, Cai D. Therapeutic effect of Yang-Xue-Qing-Nao granules on sleep dysfunction in Parkinson’s disease[J]. Chin Med. 2013, 8:14 doi:10.1186/1749-8546-8-14. 4. Pan W, Kwak S, Liu Y, Sun Y, Fang Z, Qin B, Yamamoto Y. Traditional Chinese medicine improves activities of daily living in Parkinson’s disease. Parkinson’s Disease. 2011. doi:10.4061/2011/789506.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/traditional-chinese-medicine-in-treating-for-salivation-and-nocturia-for-patient-with-parkinsons-disease/