Objective: In this study,we were to investigate imaging characteristics of 18F-FDG PET/CT in patients with Parkinson’s disease (PD), and explore its value on PD.

Background: 11C-CFT dopamine transporer (DAT) positron emission tomography (PET) has important value on the diagnosis of Parkinson’s disease ,but the imaging agent is expensive and scarce. 18F-FDG is the most common imaging agent, and its role in Parkinson’s disease is to be developed.

Methods: (1) Using UPDRS-III score, Hoehn-Yahr (H-Y) score to evaluate disease duration, severity of 60 PD patients, 40 age- and sex-matched people without central nervous system disorders as controls; (2) 60 PD patients and 40 controls underwent brain tomography imaging by intravenous injected 18F-FDG to get the respective ratio of radioactive count per unit area of caudate nucleus, putamen, thalamus, frontal lobe, temporal lobe, parietal lobe, occipital lobe and cerebellum (Rcl/cb). According to H-Y score 60 PD patients were divided as the early, middle and late stage, compare if there were difference in ratio of radioactive count between different stages of the caudate nucleus/cerebellum, putamen/cerebellum, thalamus/cerebellum, substantia nigra red nucleus/cerebellum by ANOVA ; According to UPDRS-Ⅲscore 60 PD patients were divided into tremor-predominant (TDT), rigidity and bradykinesia predominant (ART), mixed type (MT), the correlation between UPDRS-Ⅲ score and radioactivity ratio of substantia nigra and red nucleus in PD patients with different clinical symptoms were analyzed.

Results: (1) Metabolic imaging of each brain lobe, caudate nucleus, putamen, thalamus, cerebellum, cerebral were of symmetrical distribution in control group, while in PD group each lobe of the brain hemispheres, caudate nucleus, putamen, thalamus were asymmetry reduction. (2)The uptake of 18F-FDG PET/CT in nigrostriatal system of PD patients gradually reduced with increases on the severity of the disease, a negative correlation (r = -0.709, P <0.05) with UPDRS-Ⅲscores; the longer the duration, the lower uptake ratios of caudate nucleus/cerebellum, putamen/cerebellum, thalamus/cerebellum , the substantia nigra red nucleus/cerebellum in PD; (3) The UPDRS-Ⅲscores in ART, MT, TDT patients had no significant correlation with 18F-FDG uptake ratio.

Conclusions: 18F-FDG PET/CT imaging can be used for early diagnosis and identification of disease severity of PD.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/the-study-of-18f-fdg-pet-ct-imaging-in-the-value-on-parkinsons-disease/