Objective: To explore cortisol’s impact on cognitive decline and life quality in Parkinson’s disease (PD)

Background: PD patients exhibit varied symptoms, including cognitive deficits and quality of life deterioration, potentially linked to disrupted cortisol rhythms.

Method: Cortisol levels in PD patients were measured through blood samples. Cognitive functions and quality of life were evaluated using the MMSE and MoCA scales, and the PDQ-39 questionnaire, respectively.

Results:

Decreased quality of life was observed in 62.5% of patients with increased cortisol levels, OR= 5.83, RR=2.8, x2=12.5, riser exact=0.0001, memory impairment in 53.3% of patients with increased cortisol levels. observed and OR= 4.27, RR=2.4, x2=8.3, riser exact=0.0001.A negative correlation was observed between cortisol levels and both cognitive test scores (MMSE: r = -0.45, p = 0.005; MoCA: r = -0.52, p = 0.002) and PDQ-39 scores (r = -0.60, p < 0.001), supporting the hypothesis of cortisol’s mediating role in cognitive and quality of life declines in PD patients.

Conclusion: Elevated cortisol levels significantly correlate with cognitive impairments and a reduced quality of life in PD patients. This research emphasizes the need for holistic care strategies that consider cortisol regulation to improve cognitive health and quality of life in PD management.

References: Rakhimbaeva, Gulnora Sattarovna, and Dilshoda Turdikulovna Akramova. “Role of Increasing Levels of The Hormone Cortisol in Cognitive Impairment in Parkinson’s Disease: Vascular Parkinsonism.” Eur. J. Mol. Clin. Med 7 (2020): 2987-2994.
Singh, Inderpal, et al. “To study the effect of high level of the Hormone Cortisol in Cognitive Impairment In Parkinson’s Disease.”

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MDS Abstracts - https://www.mdsabstracts.org/abstract/the-role-of-cortisol-a-mediator-in-influencing-cognitive-function/