Objective: Using Diffusion Kurtosis Imaging (DKI) to observe the structural changes of the cerebellum in patients with tremor-type Parkinson’s Disease (PD), and to provide a new idea for the diagnosis and treatment of PD.

Background: PD is a common degenerative disease of the nervous system.Now the pathogenesis of resting tremor in PD is not yet clear.

Methods: 1.A total of 36 diagnosed PD patients,which were satisfied of the UK Parkinson’s Disease Society Brain Bank clinical diagnostic criteria for PD.Tthe patients were divided into tremor-type PD group (19) and non-tremor type PD group (17) based on clinical symptoms.2.Select randomly 10 healthy people as Normal Healthy Control group,whose age,gender were matching with the selected PD patients.3.All of PD patients accomplished the Hoehn-Yahr (H-Y) stages to analyse the disease severity. 4.All of subjects examined head by 3.0TMRI,and completed conventional MRI sequences and DKI scan.Mean Kurtosis (MK), Mean Diffusion (MD), and Fractional Anisotropy (FA) were measured in bilateral cerebellar white matter and dentate nucleus.5.All of the datas was analysed by SPSS 23.0.

Results: 1.The data of three groups in age, gender and H-Y stage was not statistically significant.2.Compared with Normal Control group,the MK value of the white matter and dentate nucleus in bilateral cerebellum,the FA value of the white matter in left cerebellum in tremor-type PD group were increased,the MD value of the white matter in bilateral cerebellum in tremor-type PD group were decreased. 3.Compared with Normal Control group,the MK value of the white matter and dentate nucleus in bilateral cerebellum,the FA value of the white matter in left cerebellum in non-tremor type PD group were significantly increased.4.Compared with non-tremor type PD group,the MK value of the white matter and dentate nucleus in bilateral cerebellum,the FA value of the white matter in left cerebellum and the dentate nucleus of left cerebellum in tremor-type PD group were significantly increased.

Conclusions: 1.The white matter and dentate nucleus of cerebellum in the PD patients occur structural changes, which may play a compensatory role in the disease.2.The cerebellar structure of patients with rest tremor in PD occur changes,so as to verify the changes to the cerebellum of compensatory function, which is mediated by the cerebellar-thalamic-cortex loop.3.Compared with the FA and MD value, the sensitivity of MK value is relatively higher to organizational structure.

References: 1. Veraart J, Hecke W V, Sijbers J. Constrained maximum likelihood estimation of the diffusion kurtosis tensor using a Rician noise model. Magnetic Resonance in Medicine, 2011, 66(3):678-686. 2.Wu T, Hallett M. The cerebellum in Parkinson’s disease. Brain A Journal of Neurology, 2013, 136(3):696-709. 3. Wang J J, Lin W Y, Lu C S, et al. Parkinson disease: diagnostic utility of diffusion kurtosis imaging. Radiology, 2011, 261(1):210-7. 4. Kamagata K, Tomiyama H, Hatano T, et al. A preliminary diffusional kurtosis imaging study of Parkinson disease: comparison with conventional diffusion tensor imaging. Neuroradiology, 2014, 56(3):251-8. 5. Giannelli M, Toschi N, Passamonti L, et al. Diffusion kurtosis and diffusion-tensor MR imaging in Parkinson disease. Radiology, 2012, 265(2):646-7.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/the-research-of-the-structural-changes-of-cerebellar-tissue-in-tremor-type-parkinsons-disease-based-on-dki/