Objective: To address overall prevalence of Postural deformities(PostD) and each type of PostD (AC, TC, UC, and PS) in PD and healthy volunteers (HVs)

Background: Postural deformities (PostD), including anterocollis (AC), camptocormia (CC), and Pisa syndrome (PS), can be found. They can diminish the quality of life (QoL) in patients with Parkinson’s disease (PD). The primary objective of our study was to address the overall prevalence of PostD in Thai PD patients. We compared clinical characteristics between PostD-PD and PD patients who did not meet the definition of either type of PostD (non-PostD). We compared the degrees of axial deviation for identifying the difference between non-PostD-PD and non-PostD-healthy volunteers (HVs).

Method: One-hundred Thai PD patients and 49 HVs were recruited. Abnormal postures were evaluated using a computerized measuring program which measured the angles of the neck (NF), upper thoracic, thoracolumbar (TLF), and truncal lateral flexion (LF) from their on-site digital photographs. AC, CC, and PS were defined. Clinical characteristics, MDS-UPDRS, gait velocity, cadence, and QoL, were assessed.

Results: Thirteen of 100 PD patients showed PostD, which mainly CC (n=11), whereas 2 of 49 HVs had PostD. PostD-PD showed significantly more severe motor symptoms than non-PostD-PD (modified H&Y of 3.0 vs. 2.5, MDS-UPDRS (posture) of 3.3 vs. 2.4, a summation of axial sub-scores of 11 vs. 10, and LEDD of 1000 vs. 608 mg). A comparison between non-PostD-PD and non-PostD-HVs showed that NF, TLF, and LF of 23, 17, and 5 degrees or more gave high specificities be PD (85.7, 93.9, and 95.9%, respectively). However, their sensitivities were low.

Conclusion: The most common PostD in Thai PD patients was CC. PostD-PD was associated with high disease severity. Our findings may raise awareness for early detection of PostD in PD, leading physicians to apply an early intervention for falling prevention and improving their QoL.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/the-prevalence-and-types-of-postural-deformities-in-thai-patients-with-parkinsons-disease-a-single-center-study/