Objective: The aim of the study was to follow-up the effect of STN DBS on motor and non-motor symptoms in aPD. 

Background: A comprehensive assessment of advanced Parkinson’s disease (aPD) patients is needed before and after undergoing treatment with subthalamic nucleus deep brain stimulation (STN DBS). In addition to motor symptoms, non-motor aspects of PD are assessed, including mood, cognitive status, sleep and others. 

Methods: 14 consecutive aPD patients treated with STN DBS were recruited in this observational prospective pilot study. Before surgery (baseline) patients underwent the assessments of motor and non-motor symptoms: motor examination (in “ON” phase), cognitive assessment (by MMSE and MoCA), non-motor functions (mood, anxiety, autonomic functions, sleep, psychiatric complications, apathy) and diseases related quality of life.  The non-motor functions were measured by validated scales fulfilled by the patient or by neurologist. The same evaluation was performed six months, one, two and three  years after surgery. Student T-test was performed to compare the baseline with the follow-up evaluations.

Results: The average age of aPD patients at baseline was 57,8 +/-7,4 years, ten were male. PD duration was 13,8 +/-4,9 years, MMSE score: 28,4 +/-1,7, MoCa: 25,2 +/-3,3.

The follow up evaluations showed a stable motor and non-motor signs. The significant improvement of non-motor symptoms in general was noted at six months, of anxiety at six months and at one year, of sleep quality at six months, at one year and at two years and of the  diseases related quality of life at six months and at one year post DBS surgery.

Conclusions: STN DBS treatment of aPD patients was associated with stable or improved non-motor symptoms status up to two years post surgery.

« Back to 2017 International Congress

MDS Abstracts - https://www.mdsabstracts.org/abstract/the-non-motor-symptoms-in-parkinsonss-disease-patients-treated-with-stn-dbs-the-follow-up-study/