Objective: The objective of this study was to identify metabolic group differences between Idiopatic Parkinson’s disease patients with dementia (PDD) and without dementia (PD), by using data analysis of positron emission tomography with 18F-fluorodeoxyglucose (18F-FDG-PET) results.

Background: Prevalence of Dementia in Idiopatic Parkinson’s disease, varies from 4% to 93%, with an average of 40%.

Methods: 50 patients fulfilling Idiopatic Parkinson’s disease criteria were recruited from movement disorder clinics in Neurology department of Inonu University Medical Faculty. The patients were separated two groups: 25 patients with PD without dementia and 25 patients with PDD. Subjects with evidence of other neurological diseases were excluded from the study. The study received approval from the Inonu University ethics committee. All patients gave their written consent. Both groups were equal from the aspects of educational status and gender parameters. Once the patients neurological examination were done, Hoehn-Yahr Staging and UPDRS were applied. All patients underwent a comprehensive cognitive testing to evaluate their overall cognitive performance, and to categorize the patients into PDD and PD groups. Then, each participant underwent 18F-FDG PET imaging.

Results: We found that there was hypometabolism in the right parietal lobe in demented IPD patients compared with nondemented IPD patients (p: 0, 017). There was hypermetabolism in the pallidums of the patients PDD (right and left accordingly p:0,010, p:0,03).

Conclusions: Investigation of cognitive impairment in Parkinson’s disease as seen in previous studies was identified hypometabolism in different brain regions, some of them were consistent with the results of our study while the others were not. There is not yet a consensus in what is the functional imaging findings in Parkinson’s disease dementia. Revealing the findings of functional imaging of PDD is significant from the aspect of estimating the dementia within the preclinic period. We think that, future studies with larger groups of patients are needed to perform on this subject.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/the-evaluation-of-metabolic-differences-by-using-18f-fdg-petct-in-demented-and-non-demented-idiophatic-parkinsons-disease-patients/