Category: Parkinson's Disease: Neuroimaging
Objective: To evaluate the effect of apolipoprotein E 4 (APOE 4) on striatal vesicular monoamine transporter-2 (VMAT2) density in Parkinson’s disease (PD).To evaluate the effect of apolipoprotein E 4 (APOE 4) on striatal vesicular monoamine transporter-2 (VMAT2) density in Parkinson’s disease (PD).
Background: VMAT2 is considered to be an objective biomarker of presynaptic dopaminergic nerve terminals in the striatum of PD patients. APOE 4 is associated with the risk of early PD, and whether it has a direct effect on dopaminergic system is unclear.
Method: Longitudinal data were obtained from 19 PD patients who were classified as APOE 4 carriers (n = 7) and non-carriers (n = 12) in the Parkinson’s Progression Marker Initiative. The availability of VMAT2 in the caudate, anterior and posterior putamen was assesed using 18F-AV-133 PET at baseline and the 1- and 3-year follow-up. 18F-AV-133 striatal binding ratio (SBR) was calculated as (target region/reference region)-1 using the occipital lobe as the reference region. Independent-samples t-test and linear mixed model were used to assess the effect of APOE 4.
Results: At beasline, APOE 4 carriers showed lower 18F-AV-133 SBR than non-carriers in the caudate, anterior and posterior putamen, but not statistically significant (p > 0.05). At 1- and 3-year follow-up, APOE 4 carriers exhibited greater magnitude of longitudinal changes in straital 18F-AV-133 SBR than non-carriers, but again not statistically significant.
Conclusion: APOE 4 has no significant effect on dopaminergic system in patients with PD.
To cite this abstract in AMA style:
W. Li, R. Li, J. Lu. The effect of APOE ε4 on striatal vesicular monoamine transporter-2 density in Parkinson’s disease [abstract]. Mov Disord. 2023; 38 (suppl 1). https://www.mdsabstracts.org/abstract/the-effect-of-apoe-%ce%b54-on-striatal-vesicular-monoamine-transporter-2-density-in-parkinsons-disease/. Accessed September 7, 2024.« Back to 2023 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/the-effect-of-apoe-%ce%b54-on-striatal-vesicular-monoamine-transporter-2-density-in-parkinsons-disease/