Session Information
Date: Wednesday, June 22, 2016
Session Title: Cognitive disorders
Session Time: 12:00pm-1:30pm
Location: Exhibit Hall located in Hall B, Level 2
Objective: We investigated the clinical significance of brain microbleeds in Alzheimer’s disease patients with MPS comparing patients without MPS.
Background: Microbleeds(MBs) were observed frequently in Alzheimer’s disease(AD) and suggested to play a crucial role in the pathophysiology, but the clinical significance of them remains unclear. Mild Parkinsonian signs (MPS), including bradykinesia, rigidity, gait disturbance, and resting tremor, are commonly found during the clinical examination of older people. MPS. Bradykinesia is most important sign of Parkinson’s disease(PD), and usually assessed finger tapping task.
Methods: The study recruited 100 patients with Alzheimer’s dementia who diagnosed at the memory clinic in Seoul Medical Center in 2014. For each patients, baseline characteristics, neuropsychological tests, cerebrovascular risk factors, medial temporal lobe atrophy, and severity of small vessel disease were evaluated according to the existence of MB. All patients performed evaluation of MPS. Bradykinesia was recorded by gyrosensor. Quantitative variables representing speed (tapping/minute), amplitude (excursion angle), and slope of amplitude were extracted from kinematic data.
Results: The prevalence of MBs in patients with Alzheimer’s disease were 33%. Each MPS are not different among the groups, but patients with more than one of any MPS are more common in MB(+) group than MB(-) group. In finger tapping task, mean amplitudes are decreased in patients with MB(+) group. But other parameters are not significant difference among the three groups.
Conclusions: Patients with MB(+) group had more common MPS comparing with MB(-) group. Especially, as severity of cognitive impairment increase, the numbers of patients with more than one of MPS are increased. These results suggest that MBs may reflect the burden of MPS in AD patients.
To cite this abstract in AMA style:
J.Y. Ahn, H.T. Kim. The clinical significance of brain microbleed in Alzheimer’s disease patients with Parkinsonian signs [abstract]. Mov Disord. 2016; 31 (suppl 2). https://www.mdsabstracts.org/abstract/the-clinical-significance-of-brain-microbleed-in-alzheimers-disease-patients-with-parkinsonian-signs/. Accessed May 16, 2025.« Back to 2016 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/the-clinical-significance-of-brain-microbleed-in-alzheimers-disease-patients-with-parkinsonian-signs/