Session Information
Date: Wednesday, June 22, 2016
Session Title: Parkinson's disease: Psychiatric manifestations
Session Time: 12:00pm-1:30pm
Location: Exhibit Hall located in Hall B, Level 2
Objective: To assess cortical thickness (CT) measures, white matter (WM) microstructural damage, and resting state (RS) functional connectivity alterations in patients with Parkinson’s disease and impulse control disorder (PD-ICD) compared with controls and PD no-ICD cases matched for disease stage and duration, motor impairment, and cognitive status.
Background: Compared with PD no-ICD, PD-ICD patients show more severe psychiatric symptomatology and brain structural alterations in the meso-cortico-limbic circuit.
Methods: 85 PD patients (35 PD-ICD) and 50 controls underwent 3D T1-weighted, diffusion tensor (DT), and RS-functional MRI (RS-fMRI). CT measures were assessed using surface-based morphometry. DT metrics were explored using region-of-interest-based and tractography approaches. RS-fMRI data were analyzed using a model free approach.
Results: Compared with controls, both patient groups showed a pattern of brain structural alterations involving the basal ganglia, pyramidal and associative systems. Compared with PD no-ICD, PD-ICD patients showed reduced CT of the left precentral and superior frontal gyri, and motor and extramotor (limbic) WM tract involvement. Furthermore, compared with controls, both patient groups had an increased functional connectivity within the visual-network. Additionally, PD no-ICD showed increased functional connectivity of bilateral precentral and postcentral gyri within the sensorimotor-network compared to both controls and PD-ICD cases.
Conclusions: Relative to PD no-ICD, PD-ICD patients are characterized by a more severe involvement of frontal, meso-limbic and motor circuits. Furthermore, in PD-ICD, the lack of increased functional connectivity within the sensorimotor-network together with their cortical thinning in the same regions, suggest a greater disconnection among these systems in this condition.
Yes, at XLVI Congress of Italian Neurology Society.
To cite this abstract in AMA style:
F. Imperiale, F. Agosta, E. Canu, V. Špica, M. Jecmenica, M. Copetti, V.S. Kostic, M. Filippi. The cerebral structural and functional signatures of impulse control disorder in Parkinson’s disease [abstract]. Mov Disord. 2016; 31 (suppl 2). https://www.mdsabstracts.org/abstract/the-cerebral-structural-and-functional-signatures-of-impulse-control-disorder-in-parkinsons-disease/. Accessed November 21, 2024.« Back to 2016 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/the-cerebral-structural-and-functional-signatures-of-impulse-control-disorder-in-parkinsons-disease/