Objective: To elucidate the relationships between physical and genetics parameters in essential tremor patients and controls. Tremor is an involuntary, rhythmic shaking of any part of the body.

Background: Essential tremor (ET), one of the most common neurological disorders, is characterized by postural tremor, which worsens with movement. The hands are most commonly affected in ET, but the head, voice, legs, and trunk can also be affected.

Methods: The inherited variety of essential tremor (familial tremor) is an autosomal dominant disorder. A defective gene from just one parent is needed to pass on the condition. The study group comprised of 42 essential tremor patients and equal number of healthy normal control subjects. A physiological follow up study were conducted then the blood was collected and analyzed for cytogenetic and gene mutations studies.

Results: Slight chromosomal abnormalities were identified in the essential tremor patients when compared to the controls is more common in people age 40 and older. While the environmental agents have been proposed to play a role, genetic factors are believed to contribute to its onset. Genetic mutation had the essential tremor patients, 50 percent chance of developing the disorder for next generation.

Conclusions: ET has been hypothesized to be a risk factor for the development to Parkinson’s disease and some patients with Parkinson’s disease report along-standing history of bilateral upper extremity postural tremor long before the onset of Parkinsonian features, such as rest tremor. Although comparison of genotypes between ET patients and controls among different ethnicities may lead to the identification of disease-specific and ethnicity-specific genome variations, most insight might be gained by studying the functions of genes. Identification of the defective gene or risk allele will enable a better understanding and classification of ET, as well as genetic counselling and therapy of this disorder.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/study-on-association-between-physical-and-genetics-role-in-essential-tremor-a-case-control-study/