Session Information
Date: Wednesday, June 22, 2016
Session Title: Huntington's disease
Session Time: 12:00pm-1:30pm
Location: Exhibit Hall located in Hall B, Level 2
Objective: To evaluate long-term effects of targeted rehabilitation on postural and gait stability in the early and middle stages of Huntington disease (HD).
Background: HD is an untreatable hereditary neurodegenerative disease manifesting various types of motor disorders including stability and gait disturbances, together with cognitive and behavioral impairments. The symptomatic therapy is limited and temporary. Rehabilitation (Rhb) is considered to be beneficial in postural and gait instability treatment and prevention of falls. However, there is very limited evidence-based information on the Rhb therapy effects and no specific Rhb management.
Methods: 8 genetically verified HD patients in the early and middle stages, without severe cognitive deficit (Mini Mental State Examination >20) and without depression (Beck Depression Inventory 0-9) were examined at the baseline using UHDRS (Unified Huntington’s Disease Rating Scale), gait stability examination (Dynamic Gait Index-DGI), posturography (Limits of Stability;LOS-static, dynamic), Falls Efficacy Scale-FES (fall risk) and Clinical Global Impression-CGI (subjective effect of treatment evaluation) questionnaires. Then they underwent a 3-week inpatient rehabilitation programme including: A. individual physiotherapy focused on gait, stability and coordination, twice a day 30 min., B. 60 min of condition training, C. 30 min of occupational therapy. The follow-up testing with the same battery was realized immediately, 1 month and 3 months after completion of the rehabilitation programme.
Results: There was a statistically significant improvement in DGI (p<0.001) in all intervals compared to the baseline and in LOS-static (p=0.003) in all intervals compared to the baseline. No improvement was found in UHDRS and questionnaires (FES, CGI).
Conclusions: Specific rehabilitation methods improve the postural and gait stability in patients with HD. The effect persists at least for 3 months.
To cite this abstract in AMA style:
L. Brabcová, J. Roth, O. Horácek, M. Kolárová, H. Bozková, J. Rusz, P. Košková, K. Lísalová, F. Jancok, J. Klempír, E. Ruzicka, H. Brozová. Specific in-patient’s rehabilitation improves postural and gait instability in Huntington’s disease [abstract]. Mov Disord. 2016; 31 (suppl 2). https://www.mdsabstracts.org/abstract/specific-in-patients-rehabilitation-improves-postural-and-gait-instability-in-huntingtons-disease/. Accessed October 3, 2026.« Back to 2016 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/specific-in-patients-rehabilitation-improves-postural-and-gait-instability-in-huntingtons-disease/