Session Information
Date: Sunday, October 7, 2018
Session Title: Restless Legs Syndrome and Other Sleep Disorders
Session Time: 1:45pm-3:15pm
Location: Hall 3FG
Objective: To study the polysomnographic changes in patients of Parkinson’s disease with or without psychosis and evaluate any microarchitecture and microarchitecture changes.
Background: Parkinson’s disease (PD) is one of the most important neurodegenerative disorders of the elderly, and a leading cause of morbidity. The patients with psychosis belong to the more malignant phenotype of Parkinson’s disease. The sleep changes in this phenotype have been less characterized.
Methods: The patients of PD were recruited (after written informed consent) from the Neurology outpatient clinics and the Parkinson’s disease and Movement Disorder Clinic. The inclusion criteria were PD diagnosed on the basis of United Kingdom PD Brain Bank Criteria, the age of patients and controls between 40-70 years, subjects of either gender, right handed, a caregiver who can give reliable history and the Mini mental Status Examination Score (MMSE) ≥ 23. The patients underwent a clinical evaluation by validated scales. Patients with a clinical diagnosis of Rapid Eye Movement(REM) sleep behavior disorder (RBD) underwent one-night polysomnography (PSG) for evaluation of the sleep architecture.
Results: Overnight polysomnography were done on 31 patients of PD having RBD. Finally, 29 overnight PSG recordings were available for analysis. The total analysed patients were 29 of which 16 were with psychosis with mean age (58.69± 5.701) and 13 were without psychosis having mean age(59.77 ± 8.268). PSG was analysed in 29 cases (with psychosis =16; without psychosis = 13) and all were males in both the groups. Most of the sleep macro-architecture parameters difference between the groups were found to be non-significant except for number of sleep cycles. The number of sleep cycles in Parkinson’s disease without psychosis were (4.308±1.3156) and for those with psychosis was (3.063±1.5692) and they were found to be significantly differ with p-value (.031). There was also an alteration in spindle delta dynamics.
Conclusions: There is a significant reduction of sleep cycles in patients with PD and psychosis indicating altered physiology. These findings also support the continuum of psychosis, sleep disturbance and cognition disturbances in PD.
References: 1: Uemura Y, Nomura T, Inoue Y, Yamawaki M, Yasui K, Nakashima K. Validation of the Parkinson’s disease sleep scale in Japanese patients: a comparison study using the Pittsburgh Sleep Quality Index, the Epworth Sleepiness Scale and Polysomnography. J Neurol Sci. 2009 Dec 15;287(1-2):36-40. doi: 10.1016/j.jns.2009.09.015. Epub 2009 Oct 4. PubMed PMID: 19804890. 2: Kulisevsky J, Roldan E. Hallucinations and sleep disturbances in Parkinson’s disease. Neurology. 2004 Oct 26;63(8 Suppl 3):S28-30. Review. PubMed PMID: 15505140.
To cite this abstract in AMA style:
R. Yadav, V. Reddy, G. Kumar, L. George, A. Shashidharan, B. Kutty, P. Pal. Sleep Abnormalities in patients with Parkinson’s disease having REM sleep behaviour disorder with and without Psychosis [abstract]. Mov Disord. 2018; 33 (suppl 2). https://www.mdsabstracts.org/abstract/sleep-abnormalities-in-patients-with-parkinsons-disease-having-rem-sleep-behaviour-disorder-with-and-without-psychosis/. Accessed November 21, 2024.« Back to 2018 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/sleep-abnormalities-in-patients-with-parkinsons-disease-having-rem-sleep-behaviour-disorder-with-and-without-psychosis/