Session Information
Date: Tuesday, June 6, 2017
Session Title: Parkinson's Disease: Pathophysiology
Session Time: 1:45pm-3:15pm
Location: Exhibit Hall C
Objective:
Here we tested if p-syn deposits can be detected with the same approach in patients affected with idiopathic RBD (iRBD), as an early histopathological marker of impending synucleinopathy.
Background: Searching for phosphorylated α-synuclein (p-syn) deposits by means of skin biopsy has been reported to be an extremely sensitive method in Parkinson’s disease
Methods:
Proximal (cervical) and distal (legs) samples of skin biopsy have been obtained in 12 patients with polysomnographic-confirmed iRBD and 55 sex and age-matched healthy controls (HC). P-syn deposits were assessed by a monoclonal antibody against phosphorylated α-synuclein at Serine 129, disclosed by an immunofluorescence method. Patients underwent also an extensive work-up in order to search for non-motor symptoms and neuroimaging findings usually associated with impending neurodegeneration and to exclude subtle motor or cognitive signs.
Results:
p-syn deposits were detected in 9 (75%) out of 12 patients affected with iRBD and none of the HC. In iRBD, p-syn deposits showed a rostro-caudal gradient of sensitivity, with the highest positivity at the cervical site (67%) and the lowest one at the leg site (58%).
Conclusions: Our preliminary findings suggest that skin biopsy in patients with iRBD might be a safe and sensible procedure in order to detect p-syn deposits in the pre-motor stage of synucleinopaties.
To cite this abstract in AMA style:
E. Antelmi, V. Donadio, G. Plazzi, R. Liguori. Skin nerve phosphorylated α-synuclein deposits in idiopathic REM sleep behavior disorder. [abstract]. Mov Disord. 2017; 32 (suppl 2). https://www.mdsabstracts.org/abstract/skin-nerve-phosphorylated-%ce%b1-synuclein-deposits-in-idiopathic-rem-sleep-behavior-disorder/. Accessed September 7, 2024.« Back to 2017 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/skin-nerve-phosphorylated-%ce%b1-synuclein-deposits-in-idiopathic-rem-sleep-behavior-disorder/