Objective: To study the level of vitamin D in the serum of Parkinson’s disease patients in the involvement of disease risk.

Background: The Parkinson’s disease is a major cause of disability in the elderly. Its risk factors are relatively unknown. Recently, chronically inadequate vitamin D intake was proposed to play a significant role in the pathogenesis of Parkinson’s disease. According to the suggested biological mechanism, the Parkinson’s disease may be caused by a continuously inadequate vitamin D status leading to a chronic loss of dopaminergic neurons in the brain.Vitamin D deficiency is of particular interest because it is easily, safely, and inexpensively corrected with adequate supplementation.

Methods: The study was based on Bukhara region’s population suffering with PD, which was conducted in 2017-2018. Serum vitamin D was determined from blood of patients and control group.Plasma total 25(OH)D level was measured by a microplate enzyme immunoassay in PD patients (N=72) and controls (N=39). Serum 25(OH)D is the barometer for vitamin D status. Interpretation was as follow that 25(OH)D of < 20 ng/ml is considered to be vitamin D deficiency whereas a 25(OH)D of 21-29 ng/ml is considered to be insufficient. Statistical analysis was performed using GraphPad Prism 7 software for Mac.

Results: Gender and age at sampling of PD cases and control had no significance. Both vitamin D deficiency (total 25(OH)D<20ng/mL) and vitamin D insufficiency (total 25(OH)D<30ng/mL) are significantly associated with PD (P<0.05). Individuals with PD were three and half times as likely to be vitamin D deficient as controls ( OR: 2.3, 95% CI, 0.88–6.14) and also vitamin D insufficient patients have increased PD risk (OR:1.6, 95% CI, 0.72–3.53).We examined the relationship between symptom duration and vitamin D levels. Our data showed that total 25(OH)D concentrations were not correlated with symptom duration ( P=0.3).

Conclusions: The results are consistent with the suggestion that low serum vitamin D level predicts an elevated risk of Parkinson’s disease incidence.Because of the small number of cases and the possibility of residual confounding, large cohort studies are needed.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/relationship-of-vitamin-d-deficiency-with-parkinsons-disease-risk/