Objective: The aim of this study was to evaluate the impact of STN DBS on RS parameters in PD. We have compared disease progression in two PD groups: one treated with DBS STN and another one that obtained only medication therapy (MED).

Background: Subthalamic nucleus (STN DBS) can slow down progression of motor impairment measured as UPDRS III and also reflexive saccades (RS) in PD.

Methods: The first group (DBS group) consisted of 12 PD patients (7F, 5M, mean age 56.7 years) who underwent bilateral STN DBS. Control group (MED group) consisted of 10 patients (9F, 1M, mean age 52.8 years). The latency, amplitude, peak of velocity and time of RS were measured with the infrared oculograph (Ober, Poland) during 3 visits (V1, V2, V3). The mean period between visits was 9±3months. Measurements were performed in 2 sessions for MED group/DBS preop group, visit: S1_MEDon, S2_MEDoff and in 4 sessions for DBS postop group, visits: S1_MEDonDBSon, S2_MEDonDBSoff, S3_MEDoffDBSon, S4_MEDoffDBSoff.

Results: We have observed correlation between RS latency in OFF-sessions measured during V1/V2/V3 visits. Mean RS latency correlates with different visits: mean RS latencies in DBS group visits V3/V1 were 326.0msec/251.8msec (p<0.05), but there was a tendency to more rapid progression in V3/V2 than V2/V1. In MED group more uniform latency increase was observed: visits V3/V1; mean latency 263.7msec/211.3msec (p=0.09), V2/V1 (n.s.), V3/V2 (n.s.). UPDRS III OFF scores were significantly increased in V3/V1 time assessment: DBS group 45.0/34.4 (p<0.05), MED group 34.4/24.3 (p<0.05).

Conclusions: The strongest effect of STN DBS on RS parameters was during first 6 postoperative months. Partially supported by grant: NCN Dec-2011/03/B/ST6/03816.

Yes, IAPRD 2015.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/reflex-saccades-changes-can-estimate-long-term-symptom-progression-in-dbs-stn-and-med-parkinsons-disease-patients-pd/