Objective: Here, we report the real-world clinical outcomes associated with the use of DBS systems capable of directionality and Multiple Independent Current Control (MICC) in overall quality of life and the use of medications.

Background: Deep Brain Stimulation (DBS) is an established treatment for motor signs and fluctuations associated with Parkinson’s disease (PD). Retrospective studies can provide a relatively quick and cost-effective means to obtain data regarding various types of patient outcomes when devices are being used per standard-of-care in the real-world clinical setting, thereby contributing to real-world evidence (RWE). Here, we report clinical outcomes associated with the use of DBS systems capable of directionality and Multiple Independent Current Control (MICC).

Method: This is an international, multi-center observational study of DBS patient outcomes (NCT03664609) based on retrospective chart review. Patients assessed were implanted with a DBS system (Vercise, Boston Scientific) capable of MICC and/or directionality for use in the treatment of motor symptoms of Parkinson’s disease. Data related to disease state, motor function, and overall quality of life are collected. Additionally, reduction in anti-parkinsonian medications usage is also assessed.

Results: To date, data from 206 patients have been collected (mean age 65.0 ± 9.2 years, 68.9% male). Of the patient data currently available (n = 59), 75% (n=44) of patients reported a reduction in anti-parkinsonian medications at 12-months post-implant. A significant improvement in Quality of Life was noted among patients up to 12-months post-implant (p = 0.015).  Cognitive health as measured by multiple relevant assessment scales (e.g. BDI, MOCA, MMSE) indicates stable mental status in most patients out to 12-months post-implant. Additional data will be presented.

Conclusion: Preliminary RWE obtained from this multicenter, observational case-series demonstrates improved quality of life, decreased medication intake and overall stable mental/cognitive status in Parkinson’s disease patients at up to 12-months post-implant using a DBS system capable of directionality and Multiple Independent Current Control (MICC).

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MDS Abstracts - https://www.mdsabstracts.org/abstract/real-world-deep-brain-stimulation-outcomes-using-directional-dbs-systems-with-multiple-independent-current-control/