Objective: Identify predictors of relapse in impulse control disorders (ICD) in patients with Parkinson’s disease.

Background: Behaviors that are performed repeatedly, excessively or minimally and compulsively can interfere with the functionality of the patient with Parkinson’s Disease, these behaviors have been defined as Impulse Control Disorders. However, there is great variability in prevalence reports; This has been related to social, cultural and economic factors. Usually the risk of this has been related to the use of dopaminergic drugs, early age of diagnosis and a history of depressive symptoms. Therefore, its evaluation is complex and requires a treatment focused on pharmacological and non-pharmacological measures.

Method: Retrospective study, carried out at the National Institute of Neurology and Neurosurgery of Mexico City from 2018 to 2020. The patients exhibited a follow-up of 3 neurological consultations.The Questionnaire for Impulsive-Compulsive Disorders (QUIPS), a validated tool for diagnosing or establishing risk of impulse control disorder, was used. A comparative analysis was performed using a Wilcoxon test for related variables, a p<0.05 was considered a significant result.

Results: The percentage of patients with Impulse Control Disorder according to the evaluation was 17.6% (9/51) for the first consultation 31.3% (16/51) for the second and 25.4% (13/51) for the third. Specifically, during the second consultation, 13.7% (7/51%) of the patients presented compulsion for medications. Likewise 9.8% (5/51) patients persisted with TCI during the course of the study despite therapeutic modifications (p<0.05) eating and shopping behaviors prevailed. Other risk factors such as age clinical stage use of dopaminergic agonists or deep stimulation were not related to impulse control disorder (p>0.05).

Conclusion: The percentage of ICD in the population was significant in the three consultations (17.6%, 31.3% and 25.4%) a high percentage of persistence of ICD is maintained in this population 9.8%. This could be related to the different indications of other authors where they have described structural and/or genetic alterations that due to the nature of the present could not be described.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/predictors-of-relapse-in-impulse-control-disorders-in-patients-with-parkinsons-disease/