Session Information
Date: Wednesday, September 25, 2019
Session Title: Cognition and Cognitive Disorders
Session Time: 1:15pm-2:45pm
Location: Agora 3 East, Level 3
Objective: Evaluate whether the Montreal Cognitive Assessment (MoCA) score is predictive of Dementia Rating Scale – 2 (DRS-2) score in the clinical evaluation of deep brain stimulation (DBS) candidates, in an effort to streamline their screening process.
Background: Cognitive impairment can be one exclusionary criterion for deep brain stimulation surgery, and the Total score on the DRS-2 has frequently been used as an indicator of cognitive functioning for these patients12. However, the DRS-2 is time-consuming, and it would be helpful to know if scores on briefer cognitive screening measures can predict the DRS-2 Total score.
Method: In 46 patients being considered for deep brain stimulation surgery (32 with PD, 9 with ET, 3 with dystonia, and 2 others), the DRS-2 Total score was predicted by the score on the MoCA, age, education, sex, and race via stepwise multiple linear regression.
Results: In the first step, MoCA scores significantly predicted DRS-2 Total scores (R2 = 0.347, p < 0.001). In the second step, education significantly added to the prediction of DRS-2 Total (R2 = 0.41, p < 0.001). None of the other variables added to this prediction. In the simplest model, adding 111 (y intercept) to the MoCA yielded a good estimate of the DRS-2 Total score. Thus, a MoCA score of 25 would yield a DRS-2 score of 136.
Conclusion: Such prediction equations can aid clinicians in evaluating patients for deep brain stimulation surgery. Although considering the entire clinical presentation remains important, a rapid screening tool may aid in the identification of the most likely DBS candidates.
References: Lang, A. E. and Widner, H. (2002), Deep brain stimulation for Parkinson’s disease: Patient selection and evaluation. Mov. Disord., 17: S94-S101 Massano J. and Garrett, C. Deep brain stimulation and cognitive decline in Parkinson’s disease: a clinical review. Frontiers in Neurology. 2002;3:1–13.
To cite this abstract in AMA style:
M. Zorn, K. Duff, J. Rolston, J. Ballard, C. Aquino, P. Moretti. Predicting DRS-2 Total scores from the MoCA [abstract]. Mov Disord. 2019; 34 (suppl 2). https://www.mdsabstracts.org/abstract/predicting-drs-2-total-scores-from-the-moca/. Accessed November 21, 2024.« Back to 2019 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/predicting-drs-2-total-scores-from-the-moca/