Session Information
Date: Tuesday, September 24, 2019
Session Title: Parkinsonisms and Parkinson-Plus
Session Time: 1:45pm-3:15pm
Location: Agora 3 West, Level 3
Objective: Introduction: PCA is a clinico-radiological syndrome characterized by progressive decline in visual processing and other posterior cognitive functions, relatively intact memory and language in the early stages, and atrophy of posterior brain regions. We present a case of corticobasal degeneration as an example of the PCA-plus syndromes.
Background: Case report: A 72-year-old man with a 5 years history of progressive symptoms of bradykinesia and limb apraxia. His past medical history included cataract surgery and bilateral macular degeneration. He was treated with levodopa in the past, but after introduction of the drug the patient reported only slight and transient improvement of motor function. The neurological examination revealed mainly left-sided bradykinetic-hypertonic syndrome. Moreover, left-sided visual neglect syndrome, visuospatial dysfunction and cortical sensory signs like astereognosis were presented. In addition, the patient had mirror movements of the left upper limb. Neuropsychological assessment revealed significant deficits in visual attention, visual and spatial functions, including the features of visual agnosia, agraphia and apraxia, with relatively intact memory and language functions. A brain magnetic resonance imaging showed asymmetric cortical and subcortical atrophy including mainly parietal lobes.
Method: case report
Results: Discussion: Chronic progressive nature, the asymmetry of symptoms, the lack of response to levodopa, the presence of mirror movements and cortical sensory signs as well as the results of the brain magnetic resonance imaging and neuropsychological assessment were the basis for the suspicion of corticobasal degeneration. Standard physical therapy and occupational therapy is recommended to improve functioning in such cases. The efficacy of levodopa is usually low.
Conclusion: Key words: corticobasal degeneration, atypical parkinsonism, posterior cortical atrophy
To cite this abstract in AMA style:
H. Sienkiewicz-Jarosz, E. Bucior. Posterior cortical atrophy (PCA) attributable to corticobasal degeneration [abstract]. Mov Disord. 2019; 34 (suppl 2). https://www.mdsabstracts.org/abstract/posterior-cortical-atrophy-pca-attributable-to-corticobasal-degeneration/. Accessed May 9, 2025.« Back to 2019 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/posterior-cortical-atrophy-pca-attributable-to-corticobasal-degeneration/