Objective: (1) To investigate the role of plasma biomarkers that is known to related to Alzheimer’s disease in INPH

(2) To assess the diagnostic and prognostic value of the plasma biomarkers in INPH and AD

Background:  Idiopathic normal-pressure hydrocephalus (INPH) is an uncommon neurological disorder of uncertain origin involving enlargement of the cerebral ventricles. Currently there is no pathological hallmark for INPH. Although INPH and other neurodegenerative diseases like Alzheimer’s disease(AD) have common pathway of degenerative changes, the findings of well-known biomarkers show differences in many studies.   

Methods:  INPH and AD subjects were selected in consecutive order from a prospectively enrolled dementia registry. Forty-eight AD and twenty-nine INPH patients constituted the final sample for analysis. And we also enrolled fifty-three controls. Plasma samples were collected at the time of the initial diagnosis. Plasma lipocalin-2 (LCN2), pentraxin-3 (PTX3), chitinase 3-like 1 (CHI3L1) and soluble CD14 (sCD14) were analyzed by ELISA.

Results:  A significant increase in the mean plasma level of CHI3L1 was found in INPH compared to AD (p=0.015). And CHI3L1 and sCD14 level were higher in INPH compared to controls (CHI3L1; p<0.01, sCD14; p=0.016)  No significant difference was found in other protein biomarkers including LCN2 and PTX3.

Conclusions:  The pattern of plasma biomarkers was different in INPH compared to AD and controls.  CHI3L1 plasma levels may be useful as a biomarker to differentiate from other neurodegenerative diseases.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/plasma-biomarkers-in-idiopathic-normal-pressure-hydrocephalus/