Category: Parkinson's Disease: Non-Motor Symptoms
Objective: To analyze the presence of fatigue and related factors in a Spanish Parkinson´s disease (PD) cohort and to compare with a control group.
Background: Fatigue is considered as one of the most common and disabling symptoms of PD. It is observed even before the motor symptoms and entails a very important detriment to the quality of life of these patients.
Method: PD patients and control subjects (CS) recruited from 35 centers of Spain from the COPPADIS cohort were included in this cross-sectional study. We used a numeric rating scale (NRS), from 0 (absence of fatigue) to 10 (maximum fatigue), for both physical (PF) and mental fatigue (MF). The relationship of fatigue with motor and non-motor symptoms (NMS) and other related disease variables were analysed.
Results: A total of 694 PD patients (mean age 62.6 ± 8.9 years, 60.2% men) and 207 CS (mean age 61.0 ± 8.3 years, 49.8% men) were included. Both PF and MF NRS scores were higher in PD patients than in CS (3.0 ± 2.8 vs 1.2 ± 2.1 [p < 0.001] and 3.0 ± 2.8 vs 1.2 ± 2.1 [p<0.001], respectively). Moderate to severe fatigue (defined as NRS ≥ 4) was more frequent in PD patients than in CS: PF, 40.3% vs 12.6% (p<0.001); MF, 27.6% vs 9.8% (p<0.001). In PD patients, a near to high correlation was observed between FP and MF (r=0.590; p<0.0001). Compared to males, both PF and MF NRS scores were higher in female PD patients (3.5 ± 2.8 vs 2.5 ± 2.5 [p<0.0001] and 2.5 ± 2.8 vs 1.9 ± 2.3 [p=0.002], respectively). Tremor dominant phenotype PD patients presented lower PF (p<0.0001) and MF (p=0.05) NRS scores than indeterminate and PIGD PD phenotypes. The greatest correlation of PF was observed with mood (BDI-II [Beck Depression Inventory-II]; r=0.484; [p<0.0001]), pain (VAS-PAIN; r=0.477 [p<0.0001]), and NMS burden (NMSS [Non Motor Symptoms Scale] total score; r=0.477 [p<0.0001]) whereas for MF it was with mood (r=0.442; p<0.0001), NMS burden (r=0.423; p<0.0001), and sleep (PDSS [Parkinson´s Disease Sleep Scale]; r=-0.362; [p<0.0001]). A greater fatigue was associated with a worse health-related quality (PDQ-39SI): PF, r= 0.493 (p<0.0001); MF, r=0.466 (p<0.0001).
Conclusion: Fatigue is more frequent in PD patients than in CS. Both physical and mental fatigue are more significant in women and patients with a non-tremoric PD phenotype. A greater fatigue is associated with a greater NMS burden and a worse mood and sleep, as well as a poorer quality of life.
To cite this abstract in AMA style:
MI. Morales-Casado, N. López-Ariztegui, A. Oliviero, V. Soto-León, JC. Segundo-Rodríguez, T. Deus Fonticoba, S. Jesús, M. Aguilar, P. Pastor, LL. Planellas, M. Cosgaya, J. García-Caldentey, N. Caballol, B. Vives, J. Hernández-Vara, I. Cabo, L. López-Manzanares, I. González-Aramburu, MA. ávila-Rivera, MJ. Catalán, V. Nogueira, V. Puente, M. Ruíz-de Arcos, C. Borrué, B. Solano-Vila, M. álvarez-Sauco, L. Vela, S. Escalante, E. Cubo, F. Carrillo-Padilla, JC. Martínez-Castrillo, P. Sánchez-Alonso, MG. Alonso-Losada, P. Clavero, J. Kulisevsky, M. Blázquez-Estrada, M. Seijo, J. Ruíz-Martinez, C. Valero, M. Kurtis, O. de Fábregues, J. González-Ardura, C. Ordás, L. López-Díaz, P. Mir, P. Martínez-Martín, D. Santos-García, C. Study Group. Physical and mental fatigue in Parkinson’s Disease: analysis from COPPADIS database [abstract]. Mov Disord. 2021; 36 (suppl 1). https://www.mdsabstracts.org/abstract/physical-and-mental-fatigue-in-parkinsons-disease-analysis-from-coppadis-database/. Accessed November 21, 2024.« Back to MDS Virtual Congress 2021
MDS Abstracts - https://www.mdsabstracts.org/abstract/physical-and-mental-fatigue-in-parkinsons-disease-analysis-from-coppadis-database/