Category: Parkinson's Disease: Neuroimaging
Objective: This study aimed to visualize α-synuclein aggregates in living patients with Parkinson’s disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA).
Background: We developed an imaging probe, [18F]C05-05, for α-synuclein inclusions and demonstrated its in-vivo performance as a PET tracer in animal models[1]. Here, we report the first-in-human evaluation of [18F]C05-05 in PD, DLB, and MSA cases compared to healthy controls (HCs).
Method: Participants
Four patients with PD, one with DLB, three with MSA-P, and five HCs were recruited. All subjects were Aβ-negative according to visual inspection of [11C]PiB-PET images.
Image analysis
Standardized uptake value ratio (SUVR) images were generated from PET images at 100–120 min after [18F]C05-05 injection using cerebral deep white matter (superior corona radiata and posterior corona radiata) as a reference region. Regions of interest (ROIs) for quantitative analysis were automatically segmented from 3D T1-weighted images using the M-vision brain tool.
Results: MSA cases showed prominent radiosignal accumulations in the basal ganglia and/or middle cerebellar peduncle, similar to a previous observation with a different probe[2]. In PD and DLB, collectively referred as Lewy body diseases (LBDs), enhanced retention of [18F]C05-05 was noted around the substantia nigra according to visual reads of images. Correspondingly, ROI-based quantifications showed that the radioprobe SUVR in the substantia nigra was significantly higher in LBD patients than in the HCs. In addition, there was a significant positive correlation between the severity of motor symptoms assessed by MDS-UPDRS part III and nigral SUVRs in the LBD group.
Conclusion: Our findings support the capability of [18F]C05-05 for capturing α-synuclein aggregates in not only MSA but LBDs.
References: [1] M Ono, M Takahashi, A Shimozawa, et al., In vivo visualization of propagating α-synuclein pathologies in mouse and marmoset models by a bimodal imaging probe, C05-05. bioRxiv. 2020 DOI: 10.1101/2020.10.23.349860 PPR: PPR229812
[2] K Matsuoka, M Ono, Y Takado, et al., High-Contrast Imaging of α-Synuclein Pathologies in Living Patients with Multiple System Atrophy. Mov Disord. 2022 DOI: doi.org/10.1002/mds.29186
To cite this abstract in AMA style:
H. Endo, K. Matsuoka, Y. Kataoka, K. Tagai, K. Hirata, N. Kokubo, A. Orihara, M. Oya, H. Matsumoto, S. Kurose, M. Ichihashi, A. Oyama, S. Kitamura, H. Zhang, C. Seki, K. Takahata, T. Tokuda, M. Ono, Y. Takado, H. Shinotoh, A. Sugiyama, T. Hatano, H. Shimada, K. Kawamura, MR. Zhang, M. Higuchi. PET visualization of α-synuclein pathologies in humans using [18F]C05-05 [abstract]. Mov Disord. 2023; 38 (suppl 1). https://www.mdsabstracts.org/abstract/pet-visualization-of-%ce%b1-synuclein-pathologies-in-humans-using-18fc05-05/. Accessed September 7, 2024.« Back to 2023 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/pet-visualization-of-%ce%b1-synuclein-pathologies-in-humans-using-18fc05-05/