Objective: The purpose of the study was to determine the characteristics of the indicators of MR diffusion in children with symptomatic epilepsy with cerebral palsy.

Background: Child Cerebral palsy (CP) and epilepsy are among the most disabling diseases in children’s neurology.

Method: The study was based on the results of a survey of 54 children with symptomatic epilepsy in cerebral palsy at the age of 1–11 years. All patients underwent conventional clinical and neurological examination, with the inclusion of routine MRI. Of the 54 patients examined, 26 patients underwent MR diffusion, this category of children constituted the main group.

Results: When studying this indicator in children with symptomatic epilepsy on the background of cerebral palsy, we found a significant decrease in this indicator in the fronto-temporal region (P <0.01). To assess the results of MRI diffusion is also used the average diffusion coefficient (ADC), in children with symptomatic epilepsy with cerebral palsy, a significant increase in this indicator was observed in all the studied zones (P <0.01). Thus, in children with symptomatic epilepsy on the background of cerebral palsy, there is a significant increase ADC in the background of decreased FA in the frontotemporal lobe.

Conclusion: The obtained results prove that the MR diffusion of children with this pathology makes it possible to identify structural disorders of the brain. Proved an imbalance of neurogenesis in these children, which is characterized by a significant increase in the average diffusion capacity of the brain against a decrease in fractional anisotropy in the frontal-temporal lobe, which indicates the permeability of the myelin sheath.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/peculiarities-of-the-indicators-of-mr-diffusion-in-childrens-cerebral-palsy-with-symptomatic-epilepsy/