Objective: The aim of the study was to study the reported cases on opsoclonus-myoclonus syndrome in India and to analyze its peculiarities in comparison with experience from developed countries.

Background: The paraneoplastic association of opsoclonus-myoclonus is of substantial importance. Over a time, with advent in technology and improved awareness, there is better recognition of underlying paraneoplastic cases worldwide. However, there is scarce data from developing countries including India.

Methods: The paraneoplastic association of opsoclonus-myoclonus is of substantial importance. Over a time, with advent in technology and improved awareness, there is better recognition of underlying paraneoplastic cases worldwide. However, there is scarce data from developing countries including India.

Results: Eighteen reported papers were identified and analyzed for underlying aetiologies and clinical presentations. Earlier reports until 2010 had preponderance of adult cases with para-infectious aetiologies. Out of 24 paediatric onset opsoclonus-myoclonus syndrome reported in literature, 14 cases had underlying paraneoplastic aetiologies. Cerebral malaria, dengue fever, HIV and varicella-zoster infection were important para-infectious aetiologies.

Conclusions: There is increasing better recognition of paraneoplastic aetiologies of opsoclonus-myoclonus syndrome. However, there is still under-reporting of cases and studies on opsoclonus-myoclonus syndrome from India. There is need of studies on epidemiology and long-term outcome in India.

References: 1.Singhi P, Sahu JK, Sarkar J, Bansal D. Clinical Profile and Outcome of Children with Opsoclonus- Myoclonus Syndrome. J Child Neurol. 2014 Jan;29(1):58-61. 2.Sahu JK, Prasad K. The opsoclonus–myoclonus syndrome. Pract Neurol. 2011 Jun;11(3):160–6.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/peculiarities-of-opsoclonus-myoclonus-syndrome-in-india-a-systematic-review-of-reported-cases/