Objective: The primary outcome was assessing QoL of a cohort of patients with PD before and after undergoing DBS surgery, measured using PDQ-39 questionary. Secondary outcomes included motor symptoms according to UPDRS-III scale and metabolic effects assessed by body mass index (BMI) and waist circumference.

Background: Deep brain stimulation (DBS) is a treatment indicated in selected patients with Parkinson’s disease (PD), in whom motor fluctuations and dyskinesias predominate and in patients with poor response to best medical treatment (BMT). The identification of predictors of improvement in Quality of life (QoL) after surgery is fundamental in the selection of candidates for DBS.

Method: A prospective observational study was conducted in a tertiary hospital to compare neurostimulation plus medical therapy (DBS group) with best medical treatment alone (BMT group) in patients with PD.

Results: A total of 41 patients with PD were enrolled between 2021 and 2023: 30 patients underwent DBS surgery and 11 patients were treated with BMT alone. Participants were revaluated between 6 to 12 months after surgery. PDQ-39 SI score had a mean improvement of 42.3% in the DBS group after surgery (p<0,001). After surgery the DBS group had a mean difference of 44.5% in the PDQ-39 SI score compared to the BMT group (p<0.001). After executing a linear regression model, baseline PDQ-39 SI score explains 33.6% of QoL improvement after DBS surgery (p=0.001). No association was found between QoL and other clinical characteristics. UPDRS-III had a mean improvement of 38.7% in the DBS group after surgery, and had an improvement of 45.7% compared to the BMT group (p<0.001). There was an increase in BMI of 1.05% and 3.0 cm on waist circumference after surgery (p<0.001). No association was found between metabolic effects and the improvement of motor or QoL after surgery.

Conclusion: Preoperative PDQ-39 SI scores could be useful to guide the selection of patients for DBS surgery. Adverse effects related to DBS surgery such as metabolic features should be considered in the decision.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/pdq-39-predicts-quality-of-life-improvement-following-neurostimulation-for-parkinsons-disease-prospective-observational-study/