Objective: The aim of the present study was to assess the prevalence of hypertension according to the duration of PD.The aim of the present study was to assess the prevalence of hypertension according to the duration of PD.

Background: Contrasting evidence suggests that Parkinson’s Disease (PD) patients present with lower cardio-metabolic risk than the general population, and that lower blood pressure levels are associated with reduced risk of incident PD. Indeed, PD is characterized by an abnormal blood pressure control (cardiovascular dysautonomia) that makes treatment of hypertension challenging in such patients. The aim of the present study was to assess the prevalence of hypertension according to the duration of PD.

Method: Two-hundred-three consecutive PD patients, referred to a Tashkent Medical Academy Hospital,underwent comprehensive clinical evaluation. Diagnosis of hypertension and pharmacological treatment were assessed. The odds of suffering from hypertension were obtained for tertiles(TZ) of PD duration.

Results: Among participants (mean age 73±8 years; 37% women; median PD duration 4 [IQR1.5-6.2] years), 120 (59%) had hypertension. The prevalence of hypertension declined across increasing tertiles of disease duration (TZ1 75%, TZ2 61%, TZ3 46%; p=0.005). Similarly,prevalent use of antihypertensive agents decreased. After adjusting for potential confounders,patients in TZ2 and TZ3 were less likely (TZ2 OR 0.45, 95%CI 0.20-0.98; TZ3 OR 0.2795%CI 0.11-0.63) to suffer from hypertension as compared with those in TZ1.

Conclusion: The present study suggests that the likelihood of suffering from hypertension might decrease along the course of PD. Further longitudinal studies should assess the pathophysiology of this phenomenon, as well as the impact of reduced blood pressure levels on the survival and functional ability of patients with PD.

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MDS Abstracts - https://www.mdsabstracts.org/abstract/parkinsons-disease-correlates-with-reduced-risk-of-hypertension/