Increasing diagnostic accuracy of Multiple System Atrophy – A Videolibrary on clinical and imaging features
Objective: To provide short, high-quality videos and MRI images presenting typical MSA features to supplement new MDS-MSA criteria1. Background: The MDS criteria for the diagnosis…Ethnic Diversity and Symptomatology in Parkinson’s Disease with a Focus on Falls and Vertical Gaze Palsy
Objective: The objective of this study was to explore atypical features in the clinical phenotype of people with Parkinson’s disease (PwP) enrolled in the East…Salivary and Plasma Heme Oxygenase-1 Concentration as a New Potential Biomarker in Parkinson Disease
Objective: The objective was to assess the utility of plasma and salivary heme oxygenase-1 (HO-1) concentration as a new potential biomarker for the diagnosis of…Bedside Assessment of Downgaze Palsy by Amplitude in Patients with Progressive Supranuclear Palsy
Objective: To assess the specificity and reliability of the bedside assessment of downgaze palsy by amplitude based on the upper edge of the iris relative to…Prospective Study of Gait and Multimodal MRI Biomarkers for Multiple System Atrophy
Objective: We aimed to develop new multimodal biomarkers allowing objective monitoring of early MSA progression to improve outcome definition for future neuroprotective trials. Background: MSA…Movement disorders in Brain Sagging Syndrome- A Systematic Review
Objective: Objective: This study aims to systematically review the array of movement disorders observed in patients diagnosed with brain sagging syndrome (BSS) secondary to spontaneous…Combining alpha-synuclein PET and seeded amplification assays to improve the diagnostic accuracy of Multiple System Atrophy of the Parkinsonian subtype (MSA-P)
Objective: To determine whether the combination of spatial (PET [18F]ACI-12589) and conformational (skin seed amplification assay; SAA) a-syn data aids the early differential diagnosis of…Pharmacokinetics And Safety Of YA-101, A Dual Inhibitors Of D-Amino Acid Oxidase (DAAO) And NLRP3 Inflammasome, In Healthy Subjects: A Double-Blind, Placebo-Controlled, Randomized, Single Dose and Multiple Dose Phase I Study
Objective: To evaluate the safety, tolerability, and pharmacokinetics (PK) profile of YA-101 in healthy volunteers with single dose and multiple dose Background: Multiple System Atrophy…Explore cellular heterogeneities of orbitofrontal cortex in multiple system atrophy using spatial transcriptomics
Objective: To explore the spatial organization and cellular complexity of the orbitofrontal cortex (OFC) in multiple system atrophy (MSA) via spatial transcriptomic (SRT). Background: The…Seed Amplification Assay for the differentiation of αSyn seed subtypes
Objective: To identify soluble αSyn-seed types present in brain homogenate (BH) and CSF using αSyn seed amplification assay (synSAA) Background: Lewy bodies and neurites are…
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