Inferring Rigidity Scores in MDS-UPDRS Motor Assessment from Other Items
Objective: This study aimed to explore the possibility of inferring rigidity scores in MDS-UPDRS assessments from other items to enhance the accuracy of clinical evaluations…Introducing the molecular subtyping of Progressive Supranuclear Palsy: a proof of concept
Objective: To enhance understanding of the molecular mechanisms underlying disease heterogeneity in Progressive supranuclear palsy (PSP) Background: PSP is a 4R-tauopathy characterised by subcortical pathology…Clinical and genetic analyses of a Swedish patient series diagnosed with ataxia
Objective: In this study, we aimed to examine clinically and genetically a patient series with ataxia from southern Sweden with known or unknown genetic causes.…Characterization of the pathogenic α-Synuclein variant p.V15A in Parkinson´s disease
Objective: To investigate functional alterations of the p.V15A variant in alpha-Synuclein (α-Syn) in Parkinson's disease (PD). Background: PD is marked by the loss of dopaminergic…Efficacy and safety of clonidine for the treatment of impulse control disorder in Parkinson’s disease: a multicentre, parallel, randomised, double blind, phase 2b clinical trial
Objective: We aimed to assess whether clonidine, a specific α2-adrenergic receptor agonist, would improve impulse controls disorders (ICDs). Background: ICDs are frequently encountered in Parkinson’s…Genome-wide association identifies novel etiological insights associated with Parkinson’s Disease in African and African admixed populations
Objective: To provide a genome-wide association study (GWAS)- based insight into the genetics of Parkinson’s disease (PD) in Africans and African admixed populations. Background: Understanding…Preoperative motor deficits and depressive symptoms predict quality of life in patients with Parkinson’s disease at different time points after surgery for subthalamic stimulation.
Objective: This retrospective study explored whether preoperative motor, cognitive, and affective parameters predict QoL and QoL components at 6 and 12 months after STN-DBS surgery.…Nocturnal behavior of people with Parkinson’s disease
Objective: Compare the nocturnal energy expenditure (kcal) and activity behavior of people with PD using a real-time wearable sensor, and determine whether these outcomes differed…Automated VMAT2 [18F]AV-133 PET analysis in Parkinson’s disease
Objective: To evaluate a fully automated image analysis pipeline to process vesicular monoamine transporters type 2 (VMAT2) [18F]AV-133 tracer positron emission tomography (PET) images, by…Functional circuit abnormalities in Levodopa-induced dyskinesia in Parkinson’s disease: A systematic review
Objective: Levodopa-induced dyskinesia (LID) in Parkinson’s disease (PD) are involuntary movements caused by long-term treatment with dopaminergic replacement therapy (levodopa). During the cause of PD,…
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