Tissue-engineered nigrostriatal pathway to rebuild dopaminergic axons in Parkinson’s disease based on clinical design criteria
Objective: To create a tissue-engineered construct with the dopaminergic (DA) cell numbers, axon lengths, and functionality required to reconstruct the human nigrostriatal pathway (NSP). Background:…Persistent and efficient transduction of the putamen following gene therapy for aromatic L-amino acid decarboxylase deficiency
Objective: This study aimed to evaluate longitudinal transduction in subcortical regions and transduction of the cortico-putaminal network after putaminal AADC gene therapy. Background: Aromatic L-amino…Functional connectivity predictive of efficacy for thalamic deep brain stimulation for Tourette Syndrome
Objective: To investigate whether outcome of thalamic deep brain stimulation (DBS) for Tourette Syndrome can be predicted by functional connectivity estimates seeding from individual stimulation sites.…The Association Between Tic Disorders and Atopy
Objective: To determine whether pediatric patients with tic disorders have an altered risk of atopy when compared with controls, whether this difference in risk is…Clinical correlates of sleep disturbances in children with Tourette syndrome
Objective: Examine potential clinical correlates of sleep disturbances in children with Tourette syndrome (TS). Background: There is increasing evidence that sleep disturbances are highly prevalent…Tourette Syndrome and Driving
Objective: To determine the interference of tics in Tourette’s syndrome on driving. Background: Driving ability may be impaired in patients with various movement disorders, but…Explosive onset of tic-like movements during the COVID pandemic among patients with no previous diagnosis of tic disorders
Objective: To examine the profile, associated conditions and risk factors among patients with abrupt onset of tic-like abnormal movements and vocalizations during the COVID pandemic.…TICS WITH FITS
Objective: To emphasize the association between seizures and a seemingly uncomplicated case of tics Background: Tics are a form hyperkinetic movement disorder , which predominantly…Stereotypy after bilateral opercular infarctions.
Objective: To report a case of stereotypy after bilateral opercular infarctions. Background: Stereotypies are repetitive, patterned and purposeless involuntary behaviors that are usually distractible[1, 2].…Low Frequency Oscillations at Limbic GPi during pre-tic activity seems associated with premonitory urges in Tourette Syndrome
Objective: To analyze the GPi local field potentials (LFP) in a a GTS patient prior to tic and prior to voluntary movements. Background: Tics are…
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