Using quantitative susceptibility mapping and diffusion magnetic resonance imaging to identify structural features of early-stage Parkinson’s disease
Objective: To identify an imaging diagnostic biomarker of PD for use in clinics by applying structural magnetic resonance imaging (MRI) techniques. Background: The midbrain dopaminergic…Developing infrastructure for a multi-arm multi-stage trial in Parkinson’s
Objective: To scope and develop infrastructure for the first multi-arm multi-stage (MAMS) platform trial for Parkinson’s disease, the Edmond J Safra ACT-PD initiative (EJS ACT-PD).…Classification of extremity movements by visual observation of signal transforms
Objective: To create a tool for raters certified in the MDS-UPDRS) [1] to blindly score online signal transforms of the output of the wearable sensors to…Height and nigral neuron density in Parkinson’s disease
Objective: To investigate the possible relationship between height and the density of neurons in the substantia nigra pars compacta (SNc). Background: The dopaminergic system modulates…DystoniaBoTXNet: A Deep Learning Platform for Predictive Outcome of Botulinum Toxin Treatment in Isolated Dystonia
Objective: To develop and validate an objective measure of the botulinum toxin treatment outcome in isolated dystonia. Background: Dystonia is characterized by abnormal, often painful,…Apathy and Volume of Tissue Activated (VTA) following Bilateral Subthalamic Deep Brain Stimulation for Parkinson’s Disease: The INTREPID Cohort
Objective: To determine frequency and/or predictors of improvement or worsening of apathy, we evaluated this behavior among those who received bilateral subthalamic deep brain stimulation…Benefits and Risks of Staged Bilateral versus Unilateral VIM DBS for Essential Tremor
Objective: To compare the benefits and risks of staged bilateral versus unilateral VIM DBS using the largest ET DBS clinical trial dataset available to date.…Analysis of bilateral subthalamic nucleus deep brain stimulation in patients with monogenic forms of Parkinson’s disease: PRKN and LRRK2
Objective: The aim of this study is to compare the clinical and pharmacological response of bilateral STN DBS in patients with monogenic forms of PD…Programming Time and the Use of a Visualization Tool for DBS Programming of a Multiple-Source, Constant-Current System
Objective: To describe utilization of image-guided programming for use as a deep brain stimulation (DBS) planning tool during initial device programming in a cohort of…Determination of glycine transporter 1 levels with [3H]-NFPS binding in hemi-parkinsonian rats with L-DOPA induced dyskinesia
Objective: To determine the distribution of the glycine transporter 1 (GlyT1) in brain areas implicated in parkinsonism and L-3,4-dihydroxyphenylalanine (L-DOPA) induced dyskinesia in the 6-hydroxydopamine…
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