A Phase 1b study to test the safety, pharmacokinetics, and pharmacodynamics of a novel inflammasome inhibitor in early-stage Parkinson’s disease: Rationale and study design
Objective: To describe the study design of a Phase 1b to test the safety, pharmacokinetics, and pharmacodynamics of a novel inflammasome inhibitor in individuals with…Machine learning algorithms for classification and analysis of pen-on-paper Archimedes spirals
Objective: To classify tremor syndromes from freely hand drawn pen-on-paper Archimedes spirals using classical machine learning techniques. Background: Spiral drawings (Archimedean) are commonly used in…Focused ultrasound offers tremor relief in multiple system atrophy patients
Objective: To report on the efficacy and safety of MRI-guided focused ultrasound (FUS) VIM-thalamotomy in patients with multiple system atrophy (MSA). Background: FUS has established…Machine learning-based classification of SCA1, SCA2, and Healthy controls using graph features
Objective: To differentiate genetic variants of spinocerebellar ataxia (SCA1 and SCA2) and healthy controls using machine learning on resting-state functional Magnetic Resonance Imaging graph features.…Magnetic Resonance Image-guided high-intensity focused ultrasound (MRIgFUS) subthalamotomy in Spanish Parkinson’s disease (PD) patients.
Objective: To describe our preliminary results of MRIgFUS subthalamotomy in two PD patients. Background: MRIgFUS thalamotomy has become the preferred surgical approach for refractory essential tremor…Relationship between cholinergic basal forebrain volume and short-latency sensory afferent inhibition in Parkinson’s disease with varying degrees of cognitive performance
Objective: To assess the relationship between volumetric measures of cholinergic basal forebrain (CBF) degeneration and short-latency sensory afferent inhibition (SAI) in Parkinson’s disease (PD). Background:…Gait and Balance Characteristics in Atypical Parkinsonian Syndromes
Objective: To characterize a cohort of patients with multiple system atrophy (MSA) and progressive supranuclear gaze palsy compared to idiopathic Parkinson’s disease (IPD) patients according…Improving Dual Task Walking Control after Training with Internal-focus Strategy in Parkinson Disease with Freezing of Gait
Objective: To investigate the dual task walking training effects with different attentional focus strategies in patient with Parkinson’s Disease (PD) who had freezing of gait…Transauricular Vagus Nerve Stimulation (taVNS) for mild to moderate Parkinson’s Disease (PD)
Objective: We evaluated feasibility, safety, and preliminary efficacy of taVNS for motor and non-motor symptoms in mild to moderate PD. Background: Neuronal loss in the…Bilateral Magnetic Resonance Imaging-Guided Focused Ultrasound Thalamotomy in Medication-Resistant Essential Tremor Treatment.
Objective: To assess the efficacy and safety of bilateral magnetic resonance imaging-guided focused ultrasound thalamothomy for medication refractory essential tremor in prospective observation of two…
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