A tau-directed monoclonal antibody could alter the tau pathology of progressive supranuclear palsy
Objective: The purpose of this study is to examine the modification of tau pathology in brain regions of a patient with progressive supranuclear palsy (PSP)…Association between severity of freezing of gait and turning characteristics in Parkinson’s disease
Objective: To investigate the turning characteristics of people with Parkinson’s disease (PD) with freezing of gait (FoG) according to the turning direction. Background: For people…Leveraging MRI and machine-learning for early detection of cognitive impairment in Parkinson’s disease
Objective: To develop a machine learning model using MRI data that predicts the likelihood of cognitive impairment in newly diagnosed patients with Parkinson's disease (PD).…Neuromelanin related 7T MRI of the locus coeruleus differs between Parkinson’s disease and controls
Objective: To compare the signal intensity of the substantia nigra and locus coeruleus on Magnetization Transfer 7T MRI between PD patients and healthy controls (HC)…Determination of metabotropic glutamate 2 receptor distribution with [3H]-LY-341,495 in hemi-parkinsonian rats with L-DOPA-induced dyskinesia
Objective: To determine the distribution and density of metabotropic glutamate 2 (mGlu2) receptors in the motor loop of the basal ganglia in 6-hydroxydopamine (6-OHDA)-lesioned rats…Characterisation of the pharmacokinetic profile of L-DOPA in the common marmoset
Objective: To determine the pharmacokinetic (PK) profile of L-3,4-dihydroxyphenylalanine (L-DOPA) in the common marmoset (Callithrix jacchus). Background: The common marmoset has been used to model…Rehabilitation robot-assisted gait training for Parkinson’s disease: A systematic review and meta-analysis of its effects on lower extremity dyskinesia and motor function
Objective: This systematic review and meta-analysis aimed to evaluate the efficacy of RAGT in improving lower extremity dyskinesia and motor function-related indicators, including the 10-meter…Neurotological evaluation on cerebellar ataxia with neuropathy and bilateral vestibular areflexia syndrome (canvas)
Objective: To describe the alterations observed in the vestibular testing in patients with CANVAS. Background: The Cerebellar Ataxia with Neuropathy and Bilateral Vestibular Areflexia Syndrome…The induction of mitochondrial damage by alpha synuclein In Parkinson’s disease.
Objective: Alpha synuclein aggregation have been indicted in the process of neuronal cell loss in Parkinson's disease; however, there have been several hypothesis to explain…A white matter disease with blooming grey matter
Objective: To describe a case of LMNB1-related autosomal dominant leukodystrophy with unique radiological features. Background: Autosomal dominant leukodystrophy (ADLD), caused by the duplication of the…
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