Challenges in Outcome Measure Selection in Multi-Arm Multi-Stage Clinical Trials in Parkinson Disease
Objective: The Edmond J Safra Accelerating Clinical Trials in Parkinson Disease (PD) initiative (EJS ACT-PD) aims to accelerate the identification of disease modifying treatment for…Design of a prodromal screening study for subtypes in Parkinson’s Disease
Objective: To follow-up prodromal Parkinson’s Disease (PD) subtypes in a longitudinal cohort study, validating new biomarkers and ethical guidelines for early detection of PD. Background:…Perceptions of persons with Parkinson’s disease towards telemedicine as an alternative mode of consultation: An International Pre-Implementation Survey
Objective: To assess the preferences and perceptions of persons living with Parkinson’s disease (PD) towards virtual consultations as an option for out-patient consultations. Background: Global…Phosphorylated α-synuclein at serine residue 129 decreased in Parkinson’s disease patients taking 250mg of daily niacin for six months
Objective: The main objective was to determine if α-synuclein could be modulated by niacin supplementation, contributing to improved Parkinson’s disease (PD) symptoms. Background: Niacin supplementation…Longitudinal study of clinical and neurophysiological features of essential tremor
Objective: This study investigates how motor and non-motor manifestations of essential tremor (ET) progress over time. Background: ET is a common and heterogeneous movement disorder…Network detection and connectivity analysis to predict DBS-induced ataxia in essential tremor
Objective: We aim to differentiate networks associated with deep brain stimulation (DBS) induced ataxia in essential tremor (ET) patients and test if connectivity to these…TWNK in Parkinson’s disease: a Movement Disorder and Mitochondrial Disease Center perspective study
Objective: The aim of the study was to screen for TWNK variants in an Italian cohort of Parkinson’s disease (PD) patients, and to assess the…Digital Biomarkers for Deep Brain Stimulation Programming in PD
Objective: This study investigates changes in EEG activity of Parkinson's disease (PD) patients with subthalamic nucleus (STN) deep brain stimulation (DBS) to identify neural biomarkers…Atypical parkinsonism presenting with isolated gaze palsy: implications for prognosis
Objective: To present a case of atypical presentation of Progressive Supranuclear Palsy (PSP). Background: PSP is a clinical syndrome characterized by parkinsonism, supranuclear gaze palsy…WATCH-PD: Baseline Phenotype and Longitudinal Digital Assessments in Early PD
Objective: To provide a longitudinal profile of early Parkinson’s (PD) disease progression using clinical and digital measures, and to evaluate the extent to which digital…
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