Feasibility of combining remote programming and remote monitoring towards a closed-loop DBS system
Objective: - Background: Deep Brain Stimulation (DBS) is an effective therapy for Parkinson’s Disease (PD). However, it is currently applied in an open-loop fashion and…Exploratory analysis of the effect of delayed-start prasinezumab on motor sign progression measured with the Roche PD Mobile Application v2: PASADENA Phase II Parts 1 and 2
Objective: To determine whether the positive effects of prasinezumab on motor progression measured by Roche PD Mobile Application (PASADENA study Part 1; 0-52 weeks; NCT03100149)…Dried blood and plasma spots for the measurement of neurofilament light chain and inflammatory cytokines in patients with REM sleep behaviour disorder
Objective: The objective of this study was to investigate the relationship between plasma and dried blood/ plasma spot measurements of inflammatory markers (IFN-ɣ, IL-1β, IL-6,…A double-blind randomized clinical trial to evaluate the effects of Candesartan for Cognitive and Neuropsychiatric Impairment in Parkinson’s Disease
Objective: To explore the feasibility of repurposing candesartan for the treatment of cognitive impairment and neuropsychiatric symptoms in PD. Background: There is an urgent need…Caregiver’s burden in Parkinson’s disease: A mixed methods study
Objective: This study had a two-fold aim: (i) to assess how characteristics of informal caregivers and people with PD affect caregiver burden and (ii) to…Treatment Selection in Multi-Arm Multi-Stage Clinical Trials in Parkinson Disease: The Search for the Ideal Neuroprotective Drug
Objective: The Edmond J Safra Accelerating Clinical Trials in Parkinson disease (PD) initiative (EJS ACT-PD) aims to accelerate the identification of disease modifying treatments for…Physician satisfaction from continuous telemonitoring in Parkinson’s disease
Objective: This work presents an evaluation of the satisfaction of physicians from using a continuous telemonitoring system for patients with Parkinson’s disease (PD). Background: The…Wearable Sensors for Quantitative Motor Assessments in Multiple System Atrophy
Objective: To determine the utility of quantitative wearable sensors in Multiple system atrophy (MSA). Background: Symptoms of MSA include parkinsonism, ataxia, and/or failure of the…Molecular alterations and pathological remodeling of colonic wall in patients with Parkinson’s disease
Objective: To evaluate, in an integrated manner, changes in faecal microbiota composition, morpho-functional alterations of the colonic mucosal barrier and changes of inflammatory markers in…Frequency-specific dynamics of beta oscillations: Critical for tuning adaptive DBS
Objective: Different frequencies within the beta range may have distinct temporal dynamics and an individual assessment should be performed to select the optimal feedback signal…
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