Development of C-terminal α-Synuclein Vaccine for Treatment and Prevention of Parkinson’s Disease and Other Synucleinopathies
Objective: Prothena is developing active vaccine candidates targeting α-synuclein (α-syn) epitopes shown in clinical and/or preclinical studies to disrupt synuclein pathology. These vaccines, which target…Whole exome sequencing in 62 families with early-onset movement disorders, cerebellar ataxia and hereditary spastic paraplegia from Kazakhstan, Tajikistan, and Azerbaijan
Objective: To report the results of whole-exome sequencing (WES) in 62 families with early-onset movement disorders, cerebellar ataxia, and hereditary spastic paraplegia (HSP) from Kazakhstan,…Addressing pathological alpha-synuclein aggregation using a small molecule strategy
Objective: The discovery of cell-permeable, orally bioavailable and brain penetrant small molecules with the potential of inhibiting aggregation and intracellular accumulation of pathological alpha-synuclein (a-syn)…Non-apoptotic caspase-3 activation mediates early synaptic dysfunction of indirect pathway neurons in the parkinsonian striatum
Objective: We set out to investigate whether caspase-3 plays a role in the loss of dendritic spines and the concomitant synaptic deficits that develop in…Distinct amyloid-dependent patterns of nigral dopamine depletion in Lewy body diseases
Objective: To investigate the effect of amyloid on striatal 18F-FP-CIT uptake patterns in Lewy body disease (LBD), including Parkinson’s disease (PD) and dementia with Lewy…Striatal Blood brain barrier opening in Parkinson´s disease
Objective: To test safety and feasibility of repeated low-intensity focused ultrasound (FUS) blood brain barrier opening (BBB) in the striatum of Parkinson’s disease (PD) patients.…Frequency-specific dynamics of beta oscillations: Critical for tuning adaptive DBS
Objective: Different frequencies within the beta range may have distinct temporal dynamics and an individual assessment should be performed to select the optimal feedback signal…EEG-based Mapping of Resting-state Functional Brain Networks in Patients with Parkinson’s Disease
Objective: To explore changes in directed functional connectivity in four networks, namely the sensory-motor network (SMN), ventral-attention network (VAN), dorsal-attention network (DAN), and central-executive network…Validation of a wireless Home-Based Sleep Laboratory for assessment of sleep-related disorders in Parkinson’s disease
Objective: To examine the validity of a new wireless wearable system which measures EEG, EOG and sEMG for the assessment of sleep and sleep related…Home-based transcranial static magnetic field stimulation of the motor cortex for treating levodopa-induced dyskinesias in Parkinson’s disease
Objective: To investigate the potential of transcranial static magnetic field stimulation (tSMS) as a non-pharmacological, non-invasive, home-based treatment to manage levodopa-induced dyskinesias (LIDs) in Parkinson’s…
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