Electrophysiological correlates of neurological deficits in toxic-metabolic encephalopathy
Objective: We used transcranial magnetic stimulation (TMS) paradigms reflecting GABAA, GABAB, cholinergic and glutamatergic transmission at the motor cortex level, to investigate pathophysiology of different…Heart-brain synchronization breakdown in Parkinson’s disease
Objective: To evaluate the alterations in the synchronization between central autonomic network (CAN) activity and a broad set of heart rate variability (HRV) parameters reflecting…Cerebrospinal α-synuclein RT-QuIC in pathologically-confirmed Multiple System Atrophy
Objective: To assess the sensitivity of CSF α-synuclein RT-QuIC in pathologically-confirmed MSA. Background: Multiple system atrophy (MSA) is a rare neurodegenerative disorder characterised pathologically by…Central olfactory structure atrophy is linked to synucleinopathy conversion in idiopathic REM sleep behavior disorder
Objective: We hypothesized that early structural changes in the brain olfactory relevant structures may help early identification of those at risk of future disease conversion…MIBG uptakes in the major salivary glands among Lewy body disease using a semi-automatic quantitative method
Objective: The purpose of the study is to analyze 123I-metaiodobenzhylguanidine (MIBG) uptakes in the submandibular and parotid glands in patient with Lewy body disease (LBD)…Beyond the subthalamic nucleus: tractography patterns of Magnetic Resonance-guided Focused Ultrasound subthalamotomy
Objective: To identify subthalamic clusters that predict maximum improvement in bradykinesia, rigidity and tremor. To map-out the cortical fingerprint, which predict maximum efficacy. Background: Subthalamotomy…A brainstem-oriented PET/NMR method in Parkinson’s disease
Objective: To create a voxel-based method, oriented to the brainstem and allowing the detection of Parkinson’s disease (PD) and the study of the altered connectivity…A modified Delphi panel to establish a threshold of meaningful progression on MDS-UPDRS Part III
Objective: To establish a threshold for meaningful progression on MDS-UPDRS Part III in an early-stage Parkinson's disease (PD) population (Hoehn & Yahr [H&Y] Stage I–II)…Neurovascular and immune determinants of selective vulnerability of dopaminergic neurons in Parkinson’s Disease
Objective: We aimed to investigate the contribution of glial cells activation and immune cells infiltration in the selective vulnerability of dopaminergic neurons within the midbrain…Gait analysis using Wearable Sensors: different gait metrics can differentiate Parkinson’s Disease Patients from Healthy Controls and Parkinson’s Disease patients in different medication status
Objective: To identify which gait metrics better distinguish PD-OFF from PD Best-ON and PD from HC, using a dimensionality-reduction method Background: Objective gait analysis using…
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