Microglial activation facilitates alpha synuclein propagation and neurodegeneration in αSyn preformed fibrils (PFF)-injected PD mouse model
Objective: To evaluate whether microglial activation aggravates synucleinopathy progression in Parkinson's disease (PD) mouse model. Background: Alpha-synuclein (αSyn) accumulation underlay the main pathological process of…Effect of lower limb vs. abdominal compression on mobility in orthostatic hypotension – a single-blinded, randomized, controlled, cross-over study in Parkinson’s disease
Objective: Orthostatic hypotension (OH) in Parkinson’s disease (PD) is frequent and associated with reduced quality of life and reduced activities of daily living. Abdominal binders…Neuroprotective effects of Ibudilast, a Phosphodiesterase IV inhibitor in mouse model of Parkinson’s disease
Objective: In the present study, we examined neuroprotective effects, if any, of IBD drug, a inhibitor of the phosphodiesterase IV in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse…Mutation screening and burden analysis of MED27 in dystonia in a Chinese population
Objective: We aimed to systematically evaluate the genetic associations of MED27with dystonia in a dystonia cohort. Background: Recently,Meng et alreported a novel neurodevelopmental syndrome manifested homogeneously as…DaTscan striatal binding ratio dynamics in mutations carriers at risk for Parkinson’s disease: A 2-year prospective study
Objective: To investigate the temporal dynamics of striatal binding ratios (SBRs) among individuals with Parkinson's disease (PD)-related mutations and its' association with likelihood ratio (LR)…Longitudinal white matter microstructural changes in the prodromal phase of PD: A 2 year prospective study
Objective: To prospectively investigate white matter (WM) alterations in non-manifesting carriers (NMCs) of Parkinson's disease (PD)-related mutations, and its association with likelihood ratio (LR) scores.…Post deep brain stimulation cognitive decline in GBA-related Parkinson’s disease
Objective: Neurocognitive deterioration study in GBA-related Parkinson’s disease (GBA-PD) following Deep Brain stimulation Surgery of the Sub Thalamic Nuclei (STN-DBS) Background: A faster progress of Parkinson’s…Merging global cohorts of manifesting and non-manifesting carriers of pathogenic variants in known Parkinson’s disease genes
Objective: To create a global cohort of manifesting and non-manifesting carriers of pathogenic variants in known monogenic Parkinson's disease (PD) genes, such as LRRK2, PRKN, and PINK1, to better…A child with infantile onset paroxysmal episodes of jerks and stiff limbs
Objective: To present a child with ADCY5 related movement disorder having clinical response to steroids. Background: A 17 year old female, with delayed developmental milestones…Development of a quality-of-life (QoL) questionnaire for hereditary spastic paraplegia (HSP) patients and caregivers.
Objective: Patient reported outcomes like “Health-Related Quality of Life” are one of the key outcome parameters of clinical studies. The aim of this project within…
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