Investigation of superficial brain stimulation (SBS) in Parkinsonian rats as a non-invasive alternative treatment for patients with movement disorders
Objective: To investigate repetitive transcranial magnetic stimulation (rTMS) in parkinsonian rats as a non-invasive, malleable superficial brain stimulation (SBS) alternative to DBS. Background: DBS is…Progressive myoclonic epilepsy ataxia syndrome associated with NUS1 gene mutation
Objective: To describe a rare case of NUS1 gene mutation related progressive epilepsy myoclonus ataxia syndrome. Background: Pathogenic variants of NUS1 gene have been associated…Oculomotor findings in paraneoplastic neurological syndromes with cerebellar ataxia
Objective: This study aimed to evaluate oculomotor disturbances in paraneoplastic cerebellar syndromes. Background: Paraneoplastic cerebellar syndrome is an immune-mediated disorder triggered by neoplastic lesion in…Comparing neuromelanin intensity estimation techniques for Parkinson’s disease image analysis
Objective: The objective of this study is to compare robust neuromelanin (NM) substantia nigra pars compacta (SN) and locus coeruleus (LC) quantification techniques captured in…Double-blind, randomized, crossover clinical trial to compare VIM vs PSA deep brain stimulation in patients with disabling essential tremor. Preliminary results.
Objective: To compare the safety, efficacy, energy efficiency and quality of life (QoL) outcomes of bilateral PSA-DBS vs bilateral VIM-DBS in the treatment of refractory…Apathy, white-matter microstructure, and effort-based decision making in Parkinson’s Disease
Objective: To investigate the influence of reward and effort on behavior in PD patients with and without apathy, using a drift-diffusion model to analyze neuroimage…Challenges with oral anti-parkinsonian medications and opportunities with continuous subcutaneous infusion (CSCI) of foslevodopa/foscarbidopa (LDP/CDP) for treatment of advanced Parkinson’s Disease (aPD)
Objective: To understand people with Parkinson’s (PwP) experience with their advancing disease and identify factors for PwP to initiate and continue on LDP/CDP as treatment…Spiral Tunneling Technique for passing electrode lead for Deep Brain Stimulation(DBS) surgery in Parkinson’s disease(PD)
Objective: To compare the conventional “Twist & Anti-Twist” technique and “Spiral Tunnelling Technique”(STT) for tunnelling the leads for Deep Brain Stimulation surgery in PD. Background:…Evaluation of a novel Phosphodiesterase 5 inhibitor as a potential therapeutic agent in P301S transgenic mouse model of tauopathy.
Objective: In the current study, we evaluated a newly developed compound with a 1,3,5-trisubstituted pyrazoline scaffold with an improved PDE5 inhibitory potency as a potential…Studies on mitochondrial dysfunction in the peripheral blood mononuclear cells in an ethnic Indian population of SCA 12 patients
Objective: We chose important mitochondrial genes such as ndufs5, tim22, fis1, dnm1l to understand the alterations in mitochondrial function in the peripheral blood mononuclear cells…
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