Unsupervised multimodal digital assessment of fatigue and sleep disorders in Parkinson’s disease: the IDEA-FAST study
Objective: To evaluate fatigue and sleep disorders in unsupervised conditions in neurodegenerative and autoimmune conditions using a combination of mobility, autonomic and sleep digital home…Clinical and molecular features of Tunisian patients with Biallelic mutations in Huntington’s Disease
Objective: To investigate the clinical and molecular features of HD in homozygous versus heterozygous patients. Background: Huntington’s disease (HD) is a neurodegenerative autosomal dominant disorder…Blood NfL can track progression in multiple system atrophy
Objective: To validate the role of NfL for disease progression, severity and subject trial selection in MSA. Neurofilament light (NfL) was explored in this regard though…Long-term effectiveness of adjuvant treatment with catechol-o-methyltransferase or monoamine oxidase B inhibitors compared with dopamine agonists in Parkinson’s disease uncontrolled by levodopa: final results of the PD MED LATER randomized clinical trial
Objective: PD MED LATER is a large, pragmatic trial aiming to determine which class of drug when added to levodopa provides the most effective control…Evaluation of structural brain stem measurements for the differential diagnosis of MSA and IPD
Objective: To evaluate structural brain stem measurements to differentiate multiple system atrophy (MSA) from idiopathic Parkinson‘s disease (IPD). Background: MSA is a sporadic, progressive, neurodegenerative…Factors influencing health-related quality of life of patients with spinocerebellar ataxia
Objective: The objective was to demonstrate the progression of HRQoL over time and identify factors affecting SCA patients' HRQoL. Background: Spinocerebellar ataxias (SCA) comprise a…Deep brain stimulation modulates subthalamic beta bursts related to movement velocity adjustments in Parkinson’s disease
Objective: The aim of this study was to investigate the role of subthalamic beta bursts for dynamic control of precise drawing movements. Background: The performance…Modeling Parkinson’s disease progression accounting for the effect of symptomatic treatments in the Parkinson’s Progression Markers Initiative study
Objective: To explore the natural history of Parkinson’s disease (PD) accounting for the effect of symptomatic treatments on progression by modeling the time course of…Preoperative Dyskinesia Impacts Postoperative Quality of Life in PD Patients with Subthalamic Deep Brain Stimulation
Objective: To evaluate postoperative quality of life (QoL) depending on the occurrence of dyskinesia during standardized levodopa test in patients with Parkinson’s Disease (PD) undergoing…Evaluation of possible pre-motor symptoms of Parkinson’s disease in a GBA-mutation positive cohort, as well as Gaucher disease patients.
Objective: To clinically evaluate a cohort of healthy glucocerebrosidase (GBA) mutation carriers in search of early biomarkers for neurodegeneration that may be prodromal features of…
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