Membrane-associated properties and ER stress alterations in LRRK2 I1371V patient iPSC derived neurons increase susceptibility to oxidative stress.
Objective: To evaluate the pathophysiology of the midbrain dopaminergic neurons (mDAN) derived from LRRK2 I1371V PD patient-iPSCs leading to susceptibility to oxidative stress. Background: Studies…Baseline fluid biomarkers in a phase 2 clinical trial in Parkinson’s Disease
Objective: To evaluate baseline CSF and blood-based biomarkers of pathology in early-stage Parkinson’s Disease (PD) participants in the phase 2 clinical trial PASADENA. Background: Observational…Bridging the Gap between Statistical significance and Clinical Relevance: A Systematic Review of Minimum clinically important difference (MCID) thresholds of scales reported in trials of Movement Disorders
Objective: To provide a comprehensive review of various patient-reported outcome (PROs) used in movement disorders (MD) research and their MCID values reported in literature. Background:…An in-vivo study of the integrity of the nigrostriatal pathways in drug-naive Parkinson’s disease patients using [11C]PE2I PET and neuromelanin-Magnetic Resonance Imaging
Objective: This study evaluated the relationship between the neurodegeneration of the substantia nigra neurons, assessed using Neuromelanin-sensitive MRI, and of the loss of striatal dopaminergic…Prevalence of seizures in patients with Neurodegeneration with Brain Iron Accumulation
Objective: To investigate the frequency and pattern of seizures in Neurodegeneration with brain iron accumulation (NBIA) disorders in a South Indian cohort. Background: Seizure as…The prevalence and characteristics of REM sleep behavior disorder in progressive supranuclear palsy patients.
Objective: To describe the prevalence and characteristics of RBD in patients diagnosed with PSP and to demonstrate the association with each PSP subtype. Background: Rapid…Creutzfeldt-Jakob Disease misdiagnosed as Corticobasal degeneration
Objective: We described clinical, radiologic, and neuropathological findings of a patient with Creutzfeldt-Jakob Disease who presented antemortem with clinical features suggestive of corticobasal degeneration. Background:…Wilson disease: a single-center study from Tunisia
Objective: We aimed to describe different clinical and radiological presentations of WD and insist on the necessity of early diagnosis to ensure therapeutic efficiency. Background:…Sex differences in motor response to levodopa in early Parkinson’s disease
Objective: To evaluate differences between males and females in trajectory of motor response to levodopa in early Parkinson’s disease (PD). Background: Previous research has shown…Electrophysiological correlates of the increase in rigidity with the Froment maneuver in Parkinson’s patients
Objective: To investigate the physiological basis underlying the increase of rigidity during co-innervation (Froment maneuver) in Parkinson´s disease (PD) patients and to probe whether this…
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