Huntington’s disease in Senegal Epidemiological and clinical aspects
Objective: The objective of this study was to describe the epidemiological and clinical aspects of Huntington's disease in Senegal. Background: Huntington′s disease (HD) is an…Deep brain stimulation for advanced Parkinson’s disease: Initial experience in Varna, Bulgaria
Objective: Тo present our initial experience in patient selection and the early postoperative results from bilateral subthalamic nucleus (STN) deep brain stimulation (DBS) in advanced…Curved Trajectories in Stereotactic Neurosurgery
Objective: To develop a system that permits remotely navigated curved trajectories of stereotactic electrodes Background: Stereotactic neurosurgery is restricted to linear trajectories. This limits flexibility…The effect of anti- Parkinson’s disease granules and probiotics on gastrointestinal motility in the mouse model of 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine -induced Parkinson’s disease
Objective: To investigate the effect of anti- Parkinson’s disease (anti-PD granules) and probiotics on gastrointestinal motility in the mouse model of 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine( MPTP )-induced PD. Background:…Botulinum toxin injections for lingual protrusion dystonia: a review of the muscle target and dosage
Objective: The aim of our study was to perform a literature review about the botulinum toxin types, their dosage and muscle target in the treatment…Tramadol Induces Neuroinflammation, Mitochondrial Oxidative Stress, Neurotransmitters Dysbalanced and Produced Parkinson’s Disease Like Symptoms in Experimental Wistar Rats
Objective: The current study is designed to evaluate the possible neurotoxic effects of tramadol in Wistar rats. Background: Parkinson’s disease (PD) is a chronic neurodegenerative…KINETIC 2: An ongoing phase 2b, randomized, dose-response study of SAGE-324/BIIB124 for the treatment of essential tremor
Objective: KINETIC 2 (NCT05173012) is an ongoing, phase 2b, randomized, double-blind, placebo-controlled, dose-response study that aims to evaluate the efficacy, safety, and tolerability of SAGE-324/BIIB124…Incidence of orthostatic hypotension in Parkinson´s disease patients starting antiparkinsonian treatment
Objective: The main objetive of this study is to determine the percentage of patients diagnosed with Parkinson´s disease at Infanta Sofía University Hospital between september…Inhibitory and facilitatory alterations in prodromal and de novo Parkinson’s disease
Objective: The aim of this study was to detect alterations within GABAergic, glutamatergic and cholinergic circuitries in Parkinson’s Disease (PD) patients, including de Novo PD…An evaluation of NBI-827104 for essential tremor: results from a randomized, double-blind, placebo-controlled, dose-escalation, crossover study
Objective: To evaluate the efficacy of NBI-827104 in patients with essential tremor (ET). Background: NBI-827104 is a T-type calcium channel blocker that demonstrated tremorolytic activity…
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