Efficacy and safety of Mexiletine versus Placebo in patients with myotonia: A Systematic Review and Meta-analysis
Objective: We conducted this study to be the first systematic review and meta-analysis to investigate the efficacy and safety of mexiletine in the treatment of patients…Evaluation of possible pre-motor symptoms of Parkinson’s disease in a GBA-mutation positive cohort, as well as Gaucher disease patients.
Objective: To clinically evaluate a cohort of healthy glucocerebrosidase (GBA) mutation carriers in search of early biomarkers for neurodegeneration that may be prodromal features of…AAV5-miHTT gene therapy mediates sustained mutant huntingtin lowering in brain and cerebrospinal fluid of Huntington’s disease minipigs up to 5 years
Objective: Our objective is to assess long-term safety of and durability of an adeno-associated viral vector serotype 5 encoding an engineered miRNA (AAV5-miHTT) targeting human…TREM2 maintain microglial proliferation and α-syn accumulation in PD models via the PI3K-Akt pathway
Objective: To investigate the effect and role of TREM2 in microglial proliferation, α-syn-associated pathology and dopaminergic degeneration in Parkinson’s disease (PD). Background: PD is characterised…Cerebrospinal fluid biomarkers for diagnosis of Parkinson’s disease: a systematic review and network meta-analysis
Objective: In this study, we intended to use network meta-analysis to compare the diagnostic performances of different CSF biomarkers in the diagnosis and differential diagnosis…MR-morphological changes in PD patients with heterozygous GBA mutation
Objective: This study investigates possible cerebral morphological differences between GBA-gene-mutation carriers with Parkinson´s disease (PD) and PD-patients without GBA-gene-mutation depending on in- or exclusion of…Clinical Profile Of Drug-Induced Movement Disorders In Cipto Mangunkusumo Hospital, Indonesia
Objective: We aimed to portray the clinical spectrum of Drug-induced movement disorders (DIMDs) in Cipto Mangunkusumo Hospital, Jakarta, Indonesia Background: DIMDs remain a significant burden…The impact of wearing ‘OFF’ (WO) episodes on non-motor symptoms (NMS) burden and quality of life (QoL) in Parkinson’s disease (PD) patients
Objective: To estimate the frequency and severity of NMS and their impact on QoL among patients with moderate to advanced PD with WO episodes versus…The feasibility of MRI guided focused ultrasound for posttraumatic tremor with prior hemicraniotomy and skull defect
Objective: To assess the feasibility of MRgFUS lesioning in the context of prior hemicraniotomy Background: Targeted stereotactic lesioning, using MRgFUS, is an effective treatment option…Cognitive flexibility associates with atrophy and disrupted connectivity of the cognitive cerebellum in degenerative cerebellar ataxia
Objective: This study was to investigate the features of cognitive flexibility in patients with degenerative cerebellar ataxia, and to identify the pathophysiological correlates of cognitive…
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